Cargando…

MicroRNA-503 Inhibits Non-Small Cell Lung Cancer Progression By Targeting PDK1/PI3K/AKT Pathway

OBJECTIVES: The aim of the study was to study the role of dysregulated expression of a microRNA (miRNA), miR-503, in non-small-cell lung cancer (NSCLC) and investigate the underlying mechanism. METHODS: Quantitative real-time PCR (qRT-PCR) and in situ hybridization staining (ISH) were used to evalua...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Yingying, Liao, Yuanfan, Deng, Yu, Zu, Yukun, Zhao, Bo, Li, Fan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827514/ https://www.ncbi.nlm.nih.gov/pubmed/31802909 http://dx.doi.org/10.2147/OTT.S213059

Ejemplares similares

MicroRNA-503 Exacerbates Myocardial Ischemia/Reperfusion Injury via Inhibiting PI3K/Akt- and STAT3-Dependent Prosurvival Signaling Pathways
por: He, Yanjing, et al.
Publicado: (2022)

CaMKK2 Promotes the Progression of Ovarian Carcinoma through the PI3K/PDK1/Akt Axis
por: Chen, Zhen, et al.
Publicado: (2022)

MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis
por: Caporali, Andrea, et al.
Publicado: (2011)

MicroRNA‐379 suppresses osteosarcoma progression by targeting PDK1
por: Li, Zheng, et al.
Publicado: (2016)

Retracted: CaMKK2 Promotes the Progression of Ovarian Carcinoma through the PI3K/PDK1/Akt Axis
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

MicroRNA-126-3p suppresses HeLa cell proliferation, migration and invasion, and increases apoptosis via the PI3K/PDK1/AKT pathway
por: Ichikawa, Ryoko, et al.
Publicado: (2020)

MicroRNA 375 modulates hyperglycemia-induced enteric glial cell apoptosis and Diabetes-induced gastrointestinal dysfunction by targeting Pdk1 and repressing PI3K/Akt pathway
por: Chen, Yan, et al.
Publicado: (2018)

CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency
por: Wang, Xiao Qi, et al.
Publicado: (2017)

Naomaitai Ameliorated Brain Damage in Rats with Vascular Dementia by PI3K/PDK1/AKT Signaling Pathway
por: Huang, Kui, et al.
Publicado: (2019)

Functional role of MicroRNA/PI3K/AKT axis in osteosarcoma
por: Xiang, Yubo, et al.
Publicado: (2023)

Small biomarkers with massive impacts: PI3K/AKT/mTOR signalling and microRNA crosstalk regulate nasopharyngeal carcinoma
por: LI, Hai-Long, et al.
Publicado: (2022)

Dihydroartemisinin Attenuates Hypoxia-Induced Pulmonary Hypertension Through the ELAVL2/miR-503/PI3K/AKT Axis
por: Cai, Haijian, et al.
Publicado: (2022)

Inhibiting MicroRNA-503 and MicroRNA-181d with Losartan Ameliorates Diabetic Nephropathy in KKAy Mice
por: Zhu, XinWang, et al.
Publicado: (2016)

Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway
por: Deng, Q, et al.
Publicado: (2013)

MicroRNA‐503 promotes angiotensin II‐induced cardiac fibrosis by targeting Apelin‐13
por: Zhou, Yuhong, et al.
Publicado: (2016)

microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway
por: Chen, Yiyu, et al.
Publicado: (2016)

MicroRNA-10a suppresses breast cancer progression via PI3K/Akt/mTOR pathway
por: Ke, Kongliang, et al.
Publicado: (2017)

Retraction: MicroRNA-367 promotes progression of hepatocellular carcinoma through PTEN/PI3K/AKT signaling pathway
Publicado: (2020)

MicroRNA-98-5p modulates cervical cancer progression via controlling PI3K/AKT pathway
por: Xiao, RongXin, et al.
Publicado: (2021)

MicroRNA-552 Accelerates the Progression of Gastric Cancer by Targeting FOXO1 and Regulating PI3K/AKT Pathway
por: Zhao, Yuguo, et al.
Publicado: (2021)

IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways
por: Duan, Shiyu, et al.
Publicado: (2018)

The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice
por: Giménez-Llort, Lydia, et al.
Publicado: (2020)

microRNA-503 inhibits gastric cancer cell growth and epithelial-to-mesenchymal transition
por: PENG, YANG, et al.
Publicado: (2014)

MicroRNA-503 acts as a tumor suppressor in glioblastoma for multiple antitumor effects by targeting IGF-1R
por: ZHANG, YINGYING, et al.
Publicado: (2014)

MicroRNA-221 Induces Cell Survival and Cisplatin Resistance through PI3K/Akt Pathway in Human Osteosarcoma
por: Zhao, Guangyi, et al.
Publicado: (2013)

Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma
por: Bamodu, Oluwaseun Adebayo, et al.
Publicado: (2020)

Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis
por: Reilly, Luke, et al.
Publicado: (2023)

MicroRNA‐155‐5p promotes hepatocellular carcinoma progression by suppressing PTEN through the PI3K/Akt pathway
por: Fu, Xiao, et al.
Publicado: (2017)

MicroRNA-448 inhibits the progression of retinoblastoma by directly targeting ROCK1 and regulating PI3K/AKT signalling pathway
por: Wu, Shen, et al.
Publicado: (2022)

MicroRNA-124-3p inhibited progression of nasopharyngeal carcinoma by interaction with PCDH8 and the inactivation of PI3K/AKT/mTOR pathway
por: Ye, Jiacai, et al.
Publicado: (2021)

MicroRNA-503 Acts as a Tumor Suppressor in Osteosarcoma by Targeting L1CAM
por: Chong, Yang, et al.
Publicado: (2014)

HDAC2 interacts with microRNA-503-5p to regulate SGK1 in osteoarthritis
por: Wang, Zheng, et al.
Publicado: (2021)

Correction: MicroRNA-221 Induces Cell Survival and Cisplatin Resistance through PI3K/Akt Pathway in Human Osteosarcoma
por: Zhao, Guangyi, et al.
Publicado: (2013)

MicroRNA-145 inhibits growth of laryngeal squamous cell carcinoma by targeting the PI3K/Akt signaling pathway
por: Ye, Dong, et al.
Publicado: (2019)

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition
por: Castel, Pau, et al.
Publicado: (2016)

FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer
por: Mangé, Alain, et al.
Publicado: (2019)

Correction: UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expression of PDK1 through PI3K/AKT signaling
por: Lin, Jian-Xian, et al.
Publicado: (2023)

MicroRNA-193b impairs muscle growth in mouse models of type 2 diabetes by targeting the PDK1/Akt signalling pathway
por: Yang, Shu, et al.
Publicado: (2021)

MicroRNA-766 inhibits papillary thyroid cancer progression by directly targeting insulin receptor substrate 2 and regulating the PI3K/Akt pathway
por: Zhao, Jianjie, et al.
Publicado: (2022)

MicroRNA-517c Functions as a Tumor Suppressor in Hepatocellular Carcinoma via Downregulation of KPNA2 and Inhibition of PI3K/AKT Pathway
por: Ma, Limin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0tm8hs7gcciv1u6m3ooka5tbg8