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Interleukin-1α deficiency reduces adiposity, glucose intolerance and hepatic de-novo lipogenesis in diet-induced obese mice

OBJECTIVE: While extensive research revealed that interleukin (IL)-1β contributes to insulin resistance (IR) development, the role of IL-1α in obesity and IR was scarcely studied. Using control, whole body IL-1α knockout (KO) or myeloid-cell-specific IL-1α-deficient mice, we tested the hypothesis th...

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Detalles Bibliográficos
Autores principales:	Almog, Tal, Kandel Kfir, Michal, Levkovich, Hana, Shlomai, Gadi, Barshack, Iris, Stienstra, Rinke, Lustig, Yaniv, Leikin Frenkel, Alicia, Harari, Ayelet, Bujanover, Yoram, Apte, Roni, Shaish, Aviv, Harats, Dror, Kamari, Yehuda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2019
Materias:	Obesity Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827792/ https://www.ncbi.nlm.nih.gov/pubmed/31749969 http://dx.doi.org/10.1136/bmjdrc-2019-000650

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