The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation

Skeletal muscle has a remarkable capacity to regenerate following injury, a property conferred by a resident population of muscle stem cells (MuSCs). In response to injury, MuSCs must double their cellular content to divide, a process requiring significant new biomass in the form of nucleotides, pho...

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Autores principales: Nguyen, John H., Chung, Jin D., Lynch, Gordon S., Ryall, James G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828616/
https://www.ncbi.nlm.nih.gov/pubmed/31737625
http://dx.doi.org/10.3389/fcell.2019.00254
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author Nguyen, John H.
Chung, Jin D.
Lynch, Gordon S.
Ryall, James G.
author_facet Nguyen, John H.
Chung, Jin D.
Lynch, Gordon S.
Ryall, James G.
author_sort Nguyen, John H.
collection PubMed
description Skeletal muscle has a remarkable capacity to regenerate following injury, a property conferred by a resident population of muscle stem cells (MuSCs). In response to injury, MuSCs must double their cellular content to divide, a process requiring significant new biomass in the form of nucleotides, phospholipids, and amino acids. This new biomass is derived from a series of intracellular metabolic cycles and alternative routing of carbon. In this review, we examine the link between metabolism and skeletal muscle regeneration with particular emphasis on the role of the cellular microenvironment in supporting the production of new biomass and MuSC proliferation.
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spelling pubmed-68286162019-11-15 The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation Nguyen, John H. Chung, Jin D. Lynch, Gordon S. Ryall, James G. Front Cell Dev Biol Cell and Developmental Biology Skeletal muscle has a remarkable capacity to regenerate following injury, a property conferred by a resident population of muscle stem cells (MuSCs). In response to injury, MuSCs must double their cellular content to divide, a process requiring significant new biomass in the form of nucleotides, phospholipids, and amino acids. This new biomass is derived from a series of intracellular metabolic cycles and alternative routing of carbon. In this review, we examine the link between metabolism and skeletal muscle regeneration with particular emphasis on the role of the cellular microenvironment in supporting the production of new biomass and MuSC proliferation. Frontiers Media S.A. 2019-10-29 /pmc/articles/PMC6828616/ /pubmed/31737625 http://dx.doi.org/10.3389/fcell.2019.00254 Text en Copyright © 2019 Nguyen, Chung, Lynch and Ryall. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Nguyen, John H.
Chung, Jin D.
Lynch, Gordon S.
Ryall, James G.
The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation
title The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation
title_full The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation
title_fullStr The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation
title_full_unstemmed The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation
title_short The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation
title_sort microenvironment is a critical regulator of muscle stem cell activation and proliferation
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828616/
https://www.ncbi.nlm.nih.gov/pubmed/31737625
http://dx.doi.org/10.3389/fcell.2019.00254
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