Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis

Osteoarthritis (OA), long considered a primary disorder of articular cartilage, is commonly associated with subchondral bone sclerosis. However, the cellular mechanisms responsible for changes to subchondral bone in OA, and the extent to which these changes are drivers of or a secondary reaction to...

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Detalles Bibliográficos
Autores principales: Mazur, Courtney M., Woo, Jonathon J., Yee, Cristal S., Fields, Aaron J., Acevedo, Claire, Bailey, Karsyn N., Kaya, Serra, Fowler, Tristan W., Lotz, Jeffrey C., Dang, Alexis, Kuo, Alfred C., Vail, Thomas P., Alliston, Tamara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828661/
https://www.ncbi.nlm.nih.gov/pubmed/31700695
http://dx.doi.org/10.1038/s41413-019-0070-y

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