KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2

Medulloblastoma (MB) is the most common malignant childhood brain tumor. About 30% of all MBs belong to the I molecular subgroup, characterized by constitutive activation of the Sonic Hedgehog (Hh) pathway. The Hh pathway is involved in several fundamental processes during embryogenesis and in adult...

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Detalles Bibliográficos
Autores principales: Spiombi, Eleonora, Angrisani, Annapaola, Fonte, Simone, De Feudis, Giuseppina, Fabretti, Francesca, Cucchi, Danilo, Izzo, Mariapaola, Infante, Paola, Miele, Evelina, Po, Agnese, Di Magno, Laura, Magliozzi, Roberto, Guardavaccaro, Daniele, Maroder, Marella, Canettieri, Gianluca, Giannini, Giuseppe, Ferretti, Elisabetta, Gulino, Alberto, Di Marcotullio, Lucia, Moretti, Marta, De Smaele, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828672/
https://www.ncbi.nlm.nih.gov/pubmed/31685809
http://dx.doi.org/10.1038/s41389-019-0175-6

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