A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease

Melanoma, the deadliest skin cancer, remains largely incurable at advanced stages. Currently, there is a lack of animal models that resemble human melanoma initiation and progression. Recent studies using a Tyr-CreER driven mouse model have drawn contradictory conclusions about the potential of mela...

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Detalles Bibliográficos
Autores principales: Sun, Qi, Lee, Wendy, Mohri, Yasuaki, Takeo, Makoto, Lim, Chae Ho, Xu, Xiaowei, Myung, Peggy, Atit, Radhika P., Taketo, M. Mark, Moubarak, Rana S., Schober, Markus, Osman, Iman, Gay, Denise L., Saur, Dieter, Nishimura, Emi K., Ito, Mayumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828673/
https://www.ncbi.nlm.nih.gov/pubmed/31685822
http://dx.doi.org/10.1038/s41467-019-12733-1

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