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Human papillomavirus and human telomerase RNA component gene in cervical cancer progression
This study aimed to examine hTERC gene in different grades of cervical intraepithelial neoplasia (CIN) and cervical cancer, and the association between hTERC and high risk-human papillomavirus (HR-HPV) infection. Patients who underwent cervical cancer screening at the Second Affiliated Hospital of K...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828729/ https://www.ncbi.nlm.nih.gov/pubmed/31685833 http://dx.doi.org/10.1038/s41598-019-52195-5 |
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author | Liu, Yang Fan, Pianping Yang, Yingying Xu, Changjun Huang, Yajuan Li, Daizhu Qing, Qing Sun, Chunyi Zhou, Honglin |
author_facet | Liu, Yang Fan, Pianping Yang, Yingying Xu, Changjun Huang, Yajuan Li, Daizhu Qing, Qing Sun, Chunyi Zhou, Honglin |
author_sort | Liu, Yang |
collection | PubMed |
description | This study aimed to examine hTERC gene in different grades of cervical intraepithelial neoplasia (CIN) and cervical cancer, and the association between hTERC and high risk-human papillomavirus (HR-HPV) infection. Patients who underwent cervical cancer screening at the Second Affiliated Hospital of Kunming Medical University between October 2010 and December 2011 were enrolled. All patients underwent liquid-based cytology test and hybrid capture 2 (HC2) for HPV detection. hTERC was examined using fluorescence in situ hybridization (FISH). Cervical colposcopy biopsy was performed if any of the three results was positive. HC2, FISH, and pathology were compared. A total of 1200 women underwent screening, 150 patients underwent cervical biopsy: 32 in the normal group, 38 in the CIN1 group, 66 in the CIN2/3 group, and 14 in the invasive cervical cancer group. More patients had HR-HPV infection in the CIN2/3 group and ICC group compared with the CIN1 group. hTERC increased with increasing histological dysplasia. There was significant difference in hTERC positive rate between each of the three groups. More patients with hTERC gene amplification were observed in the positive HR-HPV group than in the HR-HPV negative group. In conclusion, hTERC is a potential marker for precancerous cervical cancer lesions. hTERC might be correlated with HR-HPV infection in cervical diseases. |
format | Online Article Text |
id | pubmed-6828729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68287292019-11-12 Human papillomavirus and human telomerase RNA component gene in cervical cancer progression Liu, Yang Fan, Pianping Yang, Yingying Xu, Changjun Huang, Yajuan Li, Daizhu Qing, Qing Sun, Chunyi Zhou, Honglin Sci Rep Article This study aimed to examine hTERC gene in different grades of cervical intraepithelial neoplasia (CIN) and cervical cancer, and the association between hTERC and high risk-human papillomavirus (HR-HPV) infection. Patients who underwent cervical cancer screening at the Second Affiliated Hospital of Kunming Medical University between October 2010 and December 2011 were enrolled. All patients underwent liquid-based cytology test and hybrid capture 2 (HC2) for HPV detection. hTERC was examined using fluorescence in situ hybridization (FISH). Cervical colposcopy biopsy was performed if any of the three results was positive. HC2, FISH, and pathology were compared. A total of 1200 women underwent screening, 150 patients underwent cervical biopsy: 32 in the normal group, 38 in the CIN1 group, 66 in the CIN2/3 group, and 14 in the invasive cervical cancer group. More patients had HR-HPV infection in the CIN2/3 group and ICC group compared with the CIN1 group. hTERC increased with increasing histological dysplasia. There was significant difference in hTERC positive rate between each of the three groups. More patients with hTERC gene amplification were observed in the positive HR-HPV group than in the HR-HPV negative group. In conclusion, hTERC is a potential marker for precancerous cervical cancer lesions. hTERC might be correlated with HR-HPV infection in cervical diseases. Nature Publishing Group UK 2019-11-04 /pmc/articles/PMC6828729/ /pubmed/31685833 http://dx.doi.org/10.1038/s41598-019-52195-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Liu, Yang Fan, Pianping Yang, Yingying Xu, Changjun Huang, Yajuan Li, Daizhu Qing, Qing Sun, Chunyi Zhou, Honglin Human papillomavirus and human telomerase RNA component gene in cervical cancer progression |
title | Human papillomavirus and human telomerase RNA component gene in cervical cancer progression |
title_full | Human papillomavirus and human telomerase RNA component gene in cervical cancer progression |
title_fullStr | Human papillomavirus and human telomerase RNA component gene in cervical cancer progression |
title_full_unstemmed | Human papillomavirus and human telomerase RNA component gene in cervical cancer progression |
title_short | Human papillomavirus and human telomerase RNA component gene in cervical cancer progression |
title_sort | human papillomavirus and human telomerase rna component gene in cervical cancer progression |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828729/ https://www.ncbi.nlm.nih.gov/pubmed/31685833 http://dx.doi.org/10.1038/s41598-019-52195-5 |
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