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Activation of Piezo1 sensitizes cells to TRAIL-mediated apoptosis through mitochondrial outer membrane permeability

TRAIL specifically induces apoptosis in cancer cells without affecting healthy cells. However, TRAIL’s cancer cytotoxicity was insufficient in clinical trials. Circulatory-shear stress is known to sensitize cancer cells to TRAIL. In this study, we examine the mechanism of this TRAIL sensitization wi...

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Detalles Bibliográficos
Autores principales:	Hope, Jacob M., Lopez-Cavestany, Maria, Wang, Wenjun, Reinhart-King, Cynthia A., King, Michael R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828775/ https://www.ncbi.nlm.nih.gov/pubmed/31685811 http://dx.doi.org/10.1038/s41419-019-2063-6

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