Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus

Alzheimer’s disease (AD), the most common age-related neurodegenerative disorder, is currently conceptualized as a disease of synaptic failure. Synaptic impairments are robust within the AD brain and better correlate with dementia severity when compared with other pathological features of the diseas...

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Detalles Bibliográficos
Autores principales: Forner, Stefania, Martini, Alessandra C., Prieto, G. Aleph, Dang, Cindy T., Rodriguez-Ortiz, Carlos J., Reyes-Ruiz, Jorge Mauricio, Trujillo-Estrada, Laura, da Cunha, Celia, Andrews, Elizabeth J., Phan, Jimmy, Vu Ha, Jordan, Chang, Allissa V. Z. D., Levites, Yona, Cruz, Pedro E., Ager, Rahasson, Medeiros, Rodrigo, Kitazawa, Masashi, Glabe, Charles G., Cotman, Carl W., Golde, Todd, Baglietto-Vargas, David, LaFerla, Frank M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828807/
https://www.ncbi.nlm.nih.gov/pubmed/31685865
http://dx.doi.org/10.1038/s41598-019-52324-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828807/
https://www.ncbi.nlm.nih.gov/pubmed/31685865
http://dx.doi.org/10.1038/s41598-019-52324-0

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