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Use of Topical Nitric–Zinc Complex Solution to Treat Palmoplantar and Periungual Warts in a Pediatric Population
INTRODUCTION: Nitric–zinc complex solution (NZCS) is a topically applied solution containing nitric acid, zinc, copper, and organic acids that induce a painless caustic effect on “difficult-to-treat” warts, including palmoplantar and periungual locations. The objective of the present prospective cli...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828862/ https://www.ncbi.nlm.nih.gov/pubmed/31586309 http://dx.doi.org/10.1007/s13555-019-00330-5 |
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author | Giacaman, Aniza Granger, Corinne Aladren, Sonia Bauzá, Ana Alomar Torrens, Bárbara Riutort Mercant, María Martin-Santiago, Ana |
author_facet | Giacaman, Aniza Granger, Corinne Aladren, Sonia Bauzá, Ana Alomar Torrens, Bárbara Riutort Mercant, María Martin-Santiago, Ana |
author_sort | Giacaman, Aniza |
collection | PubMed |
description | INTRODUCTION: Nitric–zinc complex solution (NZCS) is a topically applied solution containing nitric acid, zinc, copper, and organic acids that induce a painless caustic effect on “difficult-to-treat” warts, including palmoplantar and periungual locations. The objective of the present prospective clinical study was to describe the efficacy and tolerability of NZCS in the treatment of palmoplantar and periungual warts in children. METHODS: Eligible patients were immunocompetent children and adolescents, with at least one palmoplantar or periungual wart. NZCS was topically applied every 2 weeks in clinic. Efficacy was recorded by clinical evaluation, and acceptability assessments were measured using a visual analogue scale (VAS). RESULTS: Pediatric patients (N = 12) were equally distributed by gender, and the mean age was 9.60 ± 3.34 years. The youngest patient was 4 years old. A total of 31 warts were identified: 24 periungual warts (77.4%), 2 palmar warts (6.45%), and 5 plantar warts (16.12%). We observed complete resolution in 83.9% of the warts treated with NZCS, achieving total cure considered as therapy success in 87.5% of periungual warts and 71% of palmoplantar warts, with a mean of 6.0 treatment sessions. The esthetic results evaluated by the investigator were considered excellent in 83.3% of cases and good in 16.7%. In 100% of the completely resolved cases, no scars, erythema, hyperpigmentation, hypopigmentation, or hypertrophy in the area surrounding the treated warts were observed by the investigator. The esthetic results evaluated by the patients or parents/guardians were excellent. Pain and burning sensation were minimal and well tolerated. No clinically relevant adverse events were reported. CONCLUSION: NZCS was an effective treatment of warts in this pediatric population. The painlessness, simplicity, and twice-monthly dosing regimen of this treatment represents an advantage over standard approaches. FUNDING: ISDIN. TRIAL REGISTRATION: Retrospectively registered 6 September 2019, ISRCTN90862249. |
format | Online Article Text |
id | pubmed-6828862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-68288622019-11-18 Use of Topical Nitric–Zinc Complex Solution to Treat Palmoplantar and Periungual Warts in a Pediatric Population Giacaman, Aniza Granger, Corinne Aladren, Sonia Bauzá, Ana Alomar Torrens, Bárbara Riutort Mercant, María Martin-Santiago, Ana Dermatol Ther (Heidelb) Original Research INTRODUCTION: Nitric–zinc complex solution (NZCS) is a topically applied solution containing nitric acid, zinc, copper, and organic acids that induce a painless caustic effect on “difficult-to-treat” warts, including palmoplantar and periungual locations. The objective of the present prospective clinical study was to describe the efficacy and tolerability of NZCS in the treatment of palmoplantar and periungual warts in children. METHODS: Eligible patients were immunocompetent children and adolescents, with at least one palmoplantar or periungual wart. NZCS was topically applied every 2 weeks in clinic. Efficacy was recorded by clinical evaluation, and acceptability assessments were measured using a visual analogue scale (VAS). RESULTS: Pediatric patients (N = 12) were equally distributed by gender, and the mean age was 9.60 ± 3.34 years. The youngest patient was 4 years old. A total of 31 warts were identified: 24 periungual warts (77.4%), 2 palmar warts (6.45%), and 5 plantar warts (16.12%). We observed complete resolution in 83.9% of the warts treated with NZCS, achieving total cure considered as therapy success in 87.5% of periungual warts and 71% of palmoplantar warts, with a mean of 6.0 treatment sessions. The esthetic results evaluated by the investigator were considered excellent in 83.3% of cases and good in 16.7%. In 100% of the completely resolved cases, no scars, erythema, hyperpigmentation, hypopigmentation, or hypertrophy in the area surrounding the treated warts were observed by the investigator. The esthetic results evaluated by the patients or parents/guardians were excellent. Pain and burning sensation were minimal and well tolerated. No clinically relevant adverse events were reported. CONCLUSION: NZCS was an effective treatment of warts in this pediatric population. The painlessness, simplicity, and twice-monthly dosing regimen of this treatment represents an advantage over standard approaches. FUNDING: ISDIN. TRIAL REGISTRATION: Retrospectively registered 6 September 2019, ISRCTN90862249. Springer Healthcare 2019-10-04 /pmc/articles/PMC6828862/ /pubmed/31586309 http://dx.doi.org/10.1007/s13555-019-00330-5 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Research Giacaman, Aniza Granger, Corinne Aladren, Sonia Bauzá, Ana Alomar Torrens, Bárbara Riutort Mercant, María Martin-Santiago, Ana Use of Topical Nitric–Zinc Complex Solution to Treat Palmoplantar and Periungual Warts in a Pediatric Population |
title | Use of Topical Nitric–Zinc Complex Solution to Treat Palmoplantar and Periungual Warts in a Pediatric Population |
title_full | Use of Topical Nitric–Zinc Complex Solution to Treat Palmoplantar and Periungual Warts in a Pediatric Population |
title_fullStr | Use of Topical Nitric–Zinc Complex Solution to Treat Palmoplantar and Periungual Warts in a Pediatric Population |
title_full_unstemmed | Use of Topical Nitric–Zinc Complex Solution to Treat Palmoplantar and Periungual Warts in a Pediatric Population |
title_short | Use of Topical Nitric–Zinc Complex Solution to Treat Palmoplantar and Periungual Warts in a Pediatric Population |
title_sort | use of topical nitric–zinc complex solution to treat palmoplantar and periungual warts in a pediatric population |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828862/ https://www.ncbi.nlm.nih.gov/pubmed/31586309 http://dx.doi.org/10.1007/s13555-019-00330-5 |
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