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Gut Microbiota in Bipolar Depression and Its Relationship to Brain Function: An Advanced Exploration

The mechanism of bipolar disorder is unclear. Growing evidence indicates that gut microbiota plays a pivotal role in mental disorders. This study aimed to find out changes in the gut microbiota in bipolar depression (BD) subjects following treatment with quetiapine and evaluate their correlations wi...

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Autores principales: Lu, Qiaoqiao, Lai, Jianbo, Lu, Haifeng, Ng, Chee, Huang, Tingting, Zhang, Hua, Ding, Kaijing, Wang, Zheng, Jiang, Jiajun, Hu, Jianbo, Lu, Jing, Lu, Shaojia, Mou, Tingting, Wang, Dandan, Du, Yanli, Xi, Caixi, Lyu, Hailong, Chen, Jingkai, Xu, Yi, Liu, Zhuhua, Hu, Shaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828946/
https://www.ncbi.nlm.nih.gov/pubmed/31736803
http://dx.doi.org/10.3389/fpsyt.2019.00784
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author Lu, Qiaoqiao
Lai, Jianbo
Lu, Haifeng
Ng, Chee
Huang, Tingting
Zhang, Hua
Ding, Kaijing
Wang, Zheng
Jiang, Jiajun
Hu, Jianbo
Lu, Jing
Lu, Shaojia
Mou, Tingting
Wang, Dandan
Du, Yanli
Xi, Caixi
Lyu, Hailong
Chen, Jingkai
Xu, Yi
Liu, Zhuhua
Hu, Shaohua
author_facet Lu, Qiaoqiao
Lai, Jianbo
Lu, Haifeng
Ng, Chee
Huang, Tingting
Zhang, Hua
Ding, Kaijing
Wang, Zheng
Jiang, Jiajun
Hu, Jianbo
Lu, Jing
Lu, Shaojia
Mou, Tingting
Wang, Dandan
Du, Yanli
Xi, Caixi
Lyu, Hailong
Chen, Jingkai
Xu, Yi
Liu, Zhuhua
Hu, Shaohua
author_sort Lu, Qiaoqiao
collection PubMed
description The mechanism of bipolar disorder is unclear. Growing evidence indicates that gut microbiota plays a pivotal role in mental disorders. This study aimed to find out changes in the gut microbiota in bipolar depression (BD) subjects following treatment with quetiapine and evaluate their correlations with the brain and immune function. Totally 36 subjects with BD and 27 healthy controls (HCs) were recruited. The severity of depression was evaluated with the Montgomery-Asberg depression rating scale (MADRS). At baseline, fecal samples were collected and analyzed by quantitative polymerase chain reaction (qPCR). T lymphocyte subsets were measured to examine immune function. Near-infrared spectroscopy (NIRS) was used to assess brain function. All BD subjects received quetiapine treatment (300 mg/d) for four weeks, following which the fecal microbiota and immune profiles were reexamined. Here, we first put forward the new concept of brain-gut coefficient of balance (B-G(CB)), which referred to the ratio of [oxygenated hemoglobin]/(Bifidobacteria to Enterobacteriaceae ratio), to analyze the linkage between the gut microbiota and brain function. At baseline, the CD3(+) T cell proportion was positively correlated with log(10) Enterobacter spp count, whereas the correlativity between the other bacteria and immune profiles were negative. Log(10) B-G(CB) was positively correlated with CD3(+) T cell proportion. In subjects with BD, counts of Faecalibacterium prausnitzii, Bacteroides–Prevotella group, Atopobium Cluster, Enterobacter spp, and Clostridium Cluster IV were higher, whereas the log(10) (B/E) were lower than HCs (B/E refers to Bifidobacteria to Enterobacteriaceae ratio and represents microbial colonization resistance). After treatment, MADRS scores were reduced, whereas the levels of Eubacterium rectale, Bifidobacteria, and B/E increased. The composition of the gut microbiota and its relationship to brain function were altered in BD subjects. Quetiapine treatment was effective for depression and influenced the composition of gut microbiota in patients. Clinical Trial Registration: http://www.chictr.org.cn/index.aspx, identifier ChiCTR-COC-17011401, URL: http://www.chictr.org.cn/listbycreater.aspx.
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spelling pubmed-68289462019-11-15 Gut Microbiota in Bipolar Depression and Its Relationship to Brain Function: An Advanced Exploration Lu, Qiaoqiao Lai, Jianbo Lu, Haifeng Ng, Chee Huang, Tingting Zhang, Hua Ding, Kaijing Wang, Zheng Jiang, Jiajun Hu, Jianbo Lu, Jing Lu, Shaojia Mou, Tingting Wang, Dandan Du, Yanli Xi, Caixi Lyu, Hailong Chen, Jingkai Xu, Yi Liu, Zhuhua Hu, Shaohua Front Psychiatry Psychiatry The mechanism of bipolar disorder is unclear. Growing evidence indicates that gut microbiota plays a pivotal role in mental disorders. This study aimed to find out changes in the gut microbiota in bipolar depression (BD) subjects following treatment with quetiapine and evaluate their correlations with the brain and immune function. Totally 36 subjects with BD and 27 healthy controls (HCs) were recruited. The severity of depression was evaluated with the Montgomery-Asberg depression rating scale (MADRS). At baseline, fecal samples were collected and analyzed by quantitative polymerase chain reaction (qPCR). T lymphocyte subsets were measured to examine immune function. Near-infrared spectroscopy (NIRS) was used to assess brain function. All BD subjects received quetiapine treatment (300 mg/d) for four weeks, following which the fecal microbiota and immune profiles were reexamined. Here, we first put forward the new concept of brain-gut coefficient of balance (B-G(CB)), which referred to the ratio of [oxygenated hemoglobin]/(Bifidobacteria to Enterobacteriaceae ratio), to analyze the linkage between the gut microbiota and brain function. At baseline, the CD3(+) T cell proportion was positively correlated with log(10) Enterobacter spp count, whereas the correlativity between the other bacteria and immune profiles were negative. Log(10) B-G(CB) was positively correlated with CD3(+) T cell proportion. In subjects with BD, counts of Faecalibacterium prausnitzii, Bacteroides–Prevotella group, Atopobium Cluster, Enterobacter spp, and Clostridium Cluster IV were higher, whereas the log(10) (B/E) were lower than HCs (B/E refers to Bifidobacteria to Enterobacteriaceae ratio and represents microbial colonization resistance). After treatment, MADRS scores were reduced, whereas the levels of Eubacterium rectale, Bifidobacteria, and B/E increased. The composition of the gut microbiota and its relationship to brain function were altered in BD subjects. Quetiapine treatment was effective for depression and influenced the composition of gut microbiota in patients. Clinical Trial Registration: http://www.chictr.org.cn/index.aspx, identifier ChiCTR-COC-17011401, URL: http://www.chictr.org.cn/listbycreater.aspx. Frontiers Media S.A. 2019-10-29 /pmc/articles/PMC6828946/ /pubmed/31736803 http://dx.doi.org/10.3389/fpsyt.2019.00784 Text en Copyright © 2019 Lu, Lai, Lu, Ng, Huang, Zhang, Ding, Wang, Jiang, Hu, Lu, Lu, Mou, Wang, Du, Xi, Lyu, Chen, Xu, Liu and Hu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Lu, Qiaoqiao
Lai, Jianbo
Lu, Haifeng
Ng, Chee
Huang, Tingting
Zhang, Hua
Ding, Kaijing
Wang, Zheng
Jiang, Jiajun
Hu, Jianbo
Lu, Jing
Lu, Shaojia
Mou, Tingting
Wang, Dandan
Du, Yanli
Xi, Caixi
Lyu, Hailong
Chen, Jingkai
Xu, Yi
Liu, Zhuhua
Hu, Shaohua
Gut Microbiota in Bipolar Depression and Its Relationship to Brain Function: An Advanced Exploration
title Gut Microbiota in Bipolar Depression and Its Relationship to Brain Function: An Advanced Exploration
title_full Gut Microbiota in Bipolar Depression and Its Relationship to Brain Function: An Advanced Exploration
title_fullStr Gut Microbiota in Bipolar Depression and Its Relationship to Brain Function: An Advanced Exploration
title_full_unstemmed Gut Microbiota in Bipolar Depression and Its Relationship to Brain Function: An Advanced Exploration
title_short Gut Microbiota in Bipolar Depression and Its Relationship to Brain Function: An Advanced Exploration
title_sort gut microbiota in bipolar depression and its relationship to brain function: an advanced exploration
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828946/
https://www.ncbi.nlm.nih.gov/pubmed/31736803
http://dx.doi.org/10.3389/fpsyt.2019.00784
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