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Elucidating the Molecular Determinants of Aβ Aggregation with Deep Mutational Scanning

Despite the importance of Aβ aggregation in Alzheimer’s disease etiology, our understanding of the sequence determinants of aggregation is sparse and largely derived from in vitro studies. For example, in vitro proline and alanine scanning mutagenesis of Aβ(40) proposed core regions important for ag...

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Detalles Bibliográficos
Autores principales:	Gray, Vanessa E., Sitko, Katherine, Kameni, Floriane Z. Ngako, Williamson, Miriam, Stephany, Jason J., Hasle, Nicholas, Fowler, Douglas M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2019
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829127/ https://www.ncbi.nlm.nih.gov/pubmed/31558564 http://dx.doi.org/10.1534/g3.119.400535

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