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Genome-Wide Off-Target Analysis in CRISPR-Cas9 Modified Mice and Their Offspring

The emergence of the CRISPR-Cas9 system has triggered a technical revolution in mammalian genome editing. Compared to traditional gene-targeting strategies, CRISPR-Cas9 technology offers a more efficient and cost-effective approach for generating genetically modified animal models. However, off-targ...

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Detalles Bibliográficos
Autores principales:	Dong, Yan, Li, Haimei, Zhao, Liang, Koopman, Peter, Zhang, Feng, Huang, Johnny X.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2019
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829146/ https://www.ncbi.nlm.nih.gov/pubmed/31492696 http://dx.doi.org/10.1534/g3.119.400503

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