Cargando…

Depicting Conformational Ensembles of α-Synuclein by Single Molecule Force Spectroscopy and Native Mass Spectroscopy

Description of heterogeneous molecular ensembles, such as intrinsically disordered proteins, represents a challenge in structural biology and an urgent question posed by biochemistry to interpret many physiologically important, regulatory mechanisms. Single-molecule techniques can provide a unique c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Corti, Roberta, Marrano, Claudia A., Salerno, Domenico, Brocca, Stefania, Natalello, Antonino, Santambrogio, Carlo, Legname, Giuseppe, Mantegazza, Francesco, Grandori, Rita, Cassina, Valeria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829300/ https://www.ncbi.nlm.nih.gov/pubmed/31635031 http://dx.doi.org/10.3390/ijms20205181

Ejemplares similares

Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity
por: Carija, Anita, et al.
Publicado: (2019)

Tear-Based Vibrational Spectroscopy Applied to Amyotrophic Lateral Sclerosis
por: Ami, Diletta, et al.
Publicado: (2021)

Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry
por: Luise, Arianna, et al.
Publicado: (2021)

Contribution of Infrared Spectroscopy to the Understanding of Amyloid Protein Aggregation in Complex Systems
por: Ami, Diletta, et al.
Publicado: (2022)

Diverse Metastable Structures Formed by Small Oligomers of α-Synuclein Probed by Force Spectroscopy
por: Neupane, Krishna, et al.
Publicado: (2014)

Double-stranded flanking ends affect the folding kinetics and conformational equilibrium of G-quadruplexes forming sequences within the promoter of KIT oncogene
por: Vesco, Guglielmo, et al.
Publicado: (2021)

Conformational ensemble of native α-synuclein in solution as determined by short-distance crosslinking constraint-guided discrete molecular dynamics simulations
por: Brodie, Nicholas I., et al.
Publicado: (2019)

Conformations and cryo-force spectroscopy of spray-deposited single-strand DNA on gold
por: Pawlak, Rémy, et al.
Publicado: (2019)

New views on phototransduction from atomic force microscopy and single molecule force spectroscopy on native rods
por: Maity, Sourav, et al.
Publicado: (2017)

The Ensemble of Conformations of Antifreeze Glycoproteins (AFGP8): A Study Using Nuclear Magnetic Resonance Spectroscopy
por: Her, Cheenou, et al.
Publicado: (2019)

Nanomechanics of negatively supercoiled diaminopurine-substituted DNA
por: Salerno, Domenico, et al.
Publicado: (2021)

Conformational Flexibility of the Protein Insertase BamA in the Native Asymmetric Bilayer Elucidated by ESR Spectroscopy
por: Gopinath, Aathira, et al.
Publicado: (2021)

Handbook of Molecular Force Spectroscopy
por: Noy, Aleksandr
Publicado: (2008)

Theory of rapid force spectroscopy
por: Bullerjahn, Jakob T., et al.
Publicado: (2014)

Conformational rearrangements in the transmembrane domain of CNGA1 channels revealed by single-molecule force spectroscopy
por: Maity, Sourav, et al.
Publicado: (2015)

Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy
por: Raspadori, Andrea, et al.
Publicado: (2022)

Distribution of Charged Residues Affects the Average Size and Shape of Intrinsically Disordered Proteins
por: Bianchi, Greta, et al.
Publicado: (2022)

Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods
por: Ahmed, Mustapha Carab, et al.
Publicado: (2021)

Single-Tear Proteomics: A Feasible Approach to Precision Medicine
por: Ponzini, Erika, et al.
Publicado: (2021)

Salient Features of Monomeric Alpha-Synuclein Revealed by NMR Spectroscopy
por: Kim, Do-Hyoung, et al.
Publicado: (2020)

Resolving dual binding conformations of cellulosome cohesin-dockerin complexes using single-molecule force spectroscopy
por: Jobst, Markus A, et al.
Publicado: (2015)

Corrigendum: Conformational rearrangements in the transmembrane domain of CNGA1 channels revealed by single-molecule force spectroscopy
por: Maity, Sourav, et al.
Publicado: (2017)

Force Spectroscopy and Beyond: Innovations and Opportunities
por: Nathwani, Bhavik, et al.
Publicado: (2018)

Diamond Colloidal Probe Force Spectroscopy
por: Knittel, Peter, et al.
Publicado: (2019)

Theory for nonlinear dynamic force spectroscopy
por: Björnham, Oscar, et al.
Publicado: (2016)

Force Spectroscopy on Single Molecules of Life
por: Mandal, Soumit S.
Publicado: (2020)

HspB8 interacts with BAG3 in a “native‐like” conformation forming a complex that displays chaperone‐like activity
por: Sciandrone, Barbara, et al.
Publicado: (2023)

Nanomechanics of G-quadruplexes within the promoter of the KIT oncogene
por: Buglione, Enrico, et al.
Publicado: (2021)

Conformational Ensembles of α-Synuclein Derived Peptide with Different Osmolytes from Temperature Replica Exchange Sampling
por: Jamal, Salma, et al.
Publicado: (2017)

DNP-Enhanced MAS NMR: A Tool to Snapshot Conformational Ensembles of α-Synuclein in Different States
por: Uluca, Boran, et al.
Publicado: (2018)

Spatially resolved DNP-assisted NMR illuminates the conformational ensemble of α-synuclein in intact viable cells
por: Kragelj, Jaka, et al.
Publicado: (2023)

The Clustering of mApoE Anti-Amyloidogenic Peptide on Nanoparticle Surface Does Not Alter Its Performance in Controlling Beta-Amyloid Aggregation
por: Corti, Roberta, et al.
Publicado: (2020)

DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions
por: Stadtmueller, Beth M., et al.
Publicado: (2018)

Diverse high-risk B2 and D Escherichia coli clones depicted by Fourier Transform Infrared Spectroscopy
por: Sousa, Clara, et al.
Publicado: (2013)

Intramolecular interactions stabilizing compact conformations of the intrinsically disordered kinase-inhibitor domain of Sic1: a molecular dynamics investigation
por: Lambrughi, Matteo, et al.
Publicado: (2012)

Force Measurement Enabling Precise Analysis by Dynamic Force Spectroscopy
por: Taninaka, Atsushi, et al.
Publicado: (2011)

Probing Early Misfolding Events in Prion Protein Mutants by NMR Spectroscopy
por: Giachin, Gabriele, et al.
Publicado: (2013)

The Role of Hidden Conformers in Determination of Conformational Preferences of Mefenamic Acid by NOESY Spectroscopy
por: Belov, Konstantin V., et al.
Publicado: (2022)

Missense Mutations Modify the Conformational Ensemble of the α-Synuclein Monomer Which Exhibits a Two-Phase Characteristic
por: Guzzo, Adrien, et al.
Publicado: (2021)

Taming conformational heterogeneity in and with vibrational circular dichroism spectroscopy
por: Koenis, Mark A. J., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_009uuj5477i02hng0gn91jtlcq