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Nanoparticles Targeting STATs in Cancer Therapy

Over the past decades, an increase in the incidence rate of cancer has been witnessed. Although many efforts have been made to manage and treat this life threatening condition, it is still one of the leading causes of death worldwide. Therefore, scientists have attempted to target molecular signalin...

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Autores principales: Ashrafizadeh, Milad, Ahmadi, Zahra, Kotla, Niranjan G., Afshar, Elham Ghasemipour, Samarghandian, Saeed, Mandegary, Ali, Pardakhty, Abbas, Mohammadinejad, Reza, Sethi, Gautam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829305/
https://www.ncbi.nlm.nih.gov/pubmed/31569687
http://dx.doi.org/10.3390/cells8101158
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author Ashrafizadeh, Milad
Ahmadi, Zahra
Kotla, Niranjan G.
Afshar, Elham Ghasemipour
Samarghandian, Saeed
Mandegary, Ali
Pardakhty, Abbas
Mohammadinejad, Reza
Sethi, Gautam
author_facet Ashrafizadeh, Milad
Ahmadi, Zahra
Kotla, Niranjan G.
Afshar, Elham Ghasemipour
Samarghandian, Saeed
Mandegary, Ali
Pardakhty, Abbas
Mohammadinejad, Reza
Sethi, Gautam
author_sort Ashrafizadeh, Milad
collection PubMed
description Over the past decades, an increase in the incidence rate of cancer has been witnessed. Although many efforts have been made to manage and treat this life threatening condition, it is still one of the leading causes of death worldwide. Therefore, scientists have attempted to target molecular signaling pathways involved in cancer initiation and metastasis. It has been shown that signal transducers and activator of transcription (STAT) contributes to the progression of cancer cells. This important signaling pathway is associated with a number of biological processes including cell cycle, differentiation, proliferation and apoptosis. It appears that dysregulation of the STAT signaling pathway promotes the migration, viability and malignancy of various tumor cells. Hence, there have been many attempts to target the STAT signaling pathway. However, it seems that currently applied therapeutics may not be able to effectively modulate the STAT signaling pathway and suffer from a variety of drawbacks such as low bioavailability and lack of specific tumor targeting. In the present review, we demonstrate how nanocarriers can be successfully applied for encapsulation of STAT modulators in cancer therapy.
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spelling pubmed-68293052019-11-18 Nanoparticles Targeting STATs in Cancer Therapy Ashrafizadeh, Milad Ahmadi, Zahra Kotla, Niranjan G. Afshar, Elham Ghasemipour Samarghandian, Saeed Mandegary, Ali Pardakhty, Abbas Mohammadinejad, Reza Sethi, Gautam Cells Review Over the past decades, an increase in the incidence rate of cancer has been witnessed. Although many efforts have been made to manage and treat this life threatening condition, it is still one of the leading causes of death worldwide. Therefore, scientists have attempted to target molecular signaling pathways involved in cancer initiation and metastasis. It has been shown that signal transducers and activator of transcription (STAT) contributes to the progression of cancer cells. This important signaling pathway is associated with a number of biological processes including cell cycle, differentiation, proliferation and apoptosis. It appears that dysregulation of the STAT signaling pathway promotes the migration, viability and malignancy of various tumor cells. Hence, there have been many attempts to target the STAT signaling pathway. However, it seems that currently applied therapeutics may not be able to effectively modulate the STAT signaling pathway and suffer from a variety of drawbacks such as low bioavailability and lack of specific tumor targeting. In the present review, we demonstrate how nanocarriers can be successfully applied for encapsulation of STAT modulators in cancer therapy. MDPI 2019-09-27 /pmc/articles/PMC6829305/ /pubmed/31569687 http://dx.doi.org/10.3390/cells8101158 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ashrafizadeh, Milad
Ahmadi, Zahra
Kotla, Niranjan G.
Afshar, Elham Ghasemipour
Samarghandian, Saeed
Mandegary, Ali
Pardakhty, Abbas
Mohammadinejad, Reza
Sethi, Gautam
Nanoparticles Targeting STATs in Cancer Therapy
title Nanoparticles Targeting STATs in Cancer Therapy
title_full Nanoparticles Targeting STATs in Cancer Therapy
title_fullStr Nanoparticles Targeting STATs in Cancer Therapy
title_full_unstemmed Nanoparticles Targeting STATs in Cancer Therapy
title_short Nanoparticles Targeting STATs in Cancer Therapy
title_sort nanoparticles targeting stats in cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829305/
https://www.ncbi.nlm.nih.gov/pubmed/31569687
http://dx.doi.org/10.3390/cells8101158
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