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Phosphoinositide 3-Kinase P110δ-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation

The phosphoinositide 3-kinase catalytic subunit p110δ (PI3Kδ) gene maps to a human inflammatory bowel diseases (IBD) susceptibility locus, and genetic deletion of PI3Kδ signaling causes spontaneous colitis in mice. However, little is known regarding the role of PI3Kδ on IL-10-producing B cells that...

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Detalles Bibliográficos
Autores principales:	Oka, Akihiko, Mishima, Yoshiyuki, Liu, Bo, Herzog, Jeremy W., Steinbach, Erin C., Kobayashi, Taku, Plevy, Scott E., Sartor, R. Balfour
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829312/ https://www.ncbi.nlm.nih.gov/pubmed/31546615 http://dx.doi.org/10.3390/cells8101121

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