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The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer
The Transforming Growth Factor beta (TGFβ) and Bone Morphogenic Protein (BMP) pathways intersect at multiple signaling hubs and cooperatively or counteractively participate to bring about cellular processes which are critical not only for tissue morphogenesis and organogenesis during development, bu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829314/ https://www.ncbi.nlm.nih.gov/pubmed/31547567 http://dx.doi.org/10.3390/cells8101130 |
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author | Dituri, Francesco Cossu, Carla Mancarella, Serena Giannelli, Gianluigi |
author_facet | Dituri, Francesco Cossu, Carla Mancarella, Serena Giannelli, Gianluigi |
author_sort | Dituri, Francesco |
collection | PubMed |
description | The Transforming Growth Factor beta (TGFβ) and Bone Morphogenic Protein (BMP) pathways intersect at multiple signaling hubs and cooperatively or counteractively participate to bring about cellular processes which are critical not only for tissue morphogenesis and organogenesis during development, but also for adult tissue homeostasis. The proper functioning of the TGFβ/BMP pathway depends on its communication with other signaling pathways and any deregulation leads to developmental defects or diseases, including fibrosis and cancer. In this review we explore the cellular and physio-pathological contexts in which the synergism or antagonism between the TGFβ and BMP pathways are crucial determinants for the normal developmental processes, as well as the progression of fibrosis and malignancies. |
format | Online Article Text |
id | pubmed-6829314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68293142019-11-18 The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer Dituri, Francesco Cossu, Carla Mancarella, Serena Giannelli, Gianluigi Cells Review The Transforming Growth Factor beta (TGFβ) and Bone Morphogenic Protein (BMP) pathways intersect at multiple signaling hubs and cooperatively or counteractively participate to bring about cellular processes which are critical not only for tissue morphogenesis and organogenesis during development, but also for adult tissue homeostasis. The proper functioning of the TGFβ/BMP pathway depends on its communication with other signaling pathways and any deregulation leads to developmental defects or diseases, including fibrosis and cancer. In this review we explore the cellular and physio-pathological contexts in which the synergism or antagonism between the TGFβ and BMP pathways are crucial determinants for the normal developmental processes, as well as the progression of fibrosis and malignancies. MDPI 2019-09-23 /pmc/articles/PMC6829314/ /pubmed/31547567 http://dx.doi.org/10.3390/cells8101130 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dituri, Francesco Cossu, Carla Mancarella, Serena Giannelli, Gianluigi The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer |
title | The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer |
title_full | The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer |
title_fullStr | The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer |
title_full_unstemmed | The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer |
title_short | The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer |
title_sort | interactivity between tgfβ and bmp signaling in organogenesis, fibrosis, and cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829314/ https://www.ncbi.nlm.nih.gov/pubmed/31547567 http://dx.doi.org/10.3390/cells8101130 |
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