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The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer

The Transforming Growth Factor beta (TGFβ) and Bone Morphogenic Protein (BMP) pathways intersect at multiple signaling hubs and cooperatively or counteractively participate to bring about cellular processes which are critical not only for tissue morphogenesis and organogenesis during development, bu...

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Autores principales: Dituri, Francesco, Cossu, Carla, Mancarella, Serena, Giannelli, Gianluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829314/
https://www.ncbi.nlm.nih.gov/pubmed/31547567
http://dx.doi.org/10.3390/cells8101130
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author Dituri, Francesco
Cossu, Carla
Mancarella, Serena
Giannelli, Gianluigi
author_facet Dituri, Francesco
Cossu, Carla
Mancarella, Serena
Giannelli, Gianluigi
author_sort Dituri, Francesco
collection PubMed
description The Transforming Growth Factor beta (TGFβ) and Bone Morphogenic Protein (BMP) pathways intersect at multiple signaling hubs and cooperatively or counteractively participate to bring about cellular processes which are critical not only for tissue morphogenesis and organogenesis during development, but also for adult tissue homeostasis. The proper functioning of the TGFβ/BMP pathway depends on its communication with other signaling pathways and any deregulation leads to developmental defects or diseases, including fibrosis and cancer. In this review we explore the cellular and physio-pathological contexts in which the synergism or antagonism between the TGFβ and BMP pathways are crucial determinants for the normal developmental processes, as well as the progression of fibrosis and malignancies.
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spelling pubmed-68293142019-11-18 The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer Dituri, Francesco Cossu, Carla Mancarella, Serena Giannelli, Gianluigi Cells Review The Transforming Growth Factor beta (TGFβ) and Bone Morphogenic Protein (BMP) pathways intersect at multiple signaling hubs and cooperatively or counteractively participate to bring about cellular processes which are critical not only for tissue morphogenesis and organogenesis during development, but also for adult tissue homeostasis. The proper functioning of the TGFβ/BMP pathway depends on its communication with other signaling pathways and any deregulation leads to developmental defects or diseases, including fibrosis and cancer. In this review we explore the cellular and physio-pathological contexts in which the synergism or antagonism between the TGFβ and BMP pathways are crucial determinants for the normal developmental processes, as well as the progression of fibrosis and malignancies. MDPI 2019-09-23 /pmc/articles/PMC6829314/ /pubmed/31547567 http://dx.doi.org/10.3390/cells8101130 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dituri, Francesco
Cossu, Carla
Mancarella, Serena
Giannelli, Gianluigi
The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer
title The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer
title_full The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer
title_fullStr The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer
title_full_unstemmed The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer
title_short The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer
title_sort interactivity between tgfβ and bmp signaling in organogenesis, fibrosis, and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829314/
https://www.ncbi.nlm.nih.gov/pubmed/31547567
http://dx.doi.org/10.3390/cells8101130
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