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Complementary Immunometabolic Effects of Exercise and PPARβ/δ Agonist in the Context of Diet-Induced Weight Loss in Obese Female Mice

Regular aerobic exercise, independently of weight loss, improves metabolic and anti-inflammatory states, and can be regarded as beneficial in counteracting obesity-induced low-grade inflammation. However, it is still unknown how exercise alters immunometabolism in a context of dietary changes. Agoni...

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Autores principales: Le Garf, Sébastien, Murdaca, Joseph, Mothe-Satney, Isabelle, Sibille, Brigitte, Le Menn, Gwenaëlle, Chinetti, Giulia, Neels, Jaap G., Rousseau, Anne-Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829333/
https://www.ncbi.nlm.nih.gov/pubmed/31635041
http://dx.doi.org/10.3390/ijms20205182
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author Le Garf, Sébastien
Murdaca, Joseph
Mothe-Satney, Isabelle
Sibille, Brigitte
Le Menn, Gwenaëlle
Chinetti, Giulia
Neels, Jaap G.
Rousseau, Anne-Sophie
author_facet Le Garf, Sébastien
Murdaca, Joseph
Mothe-Satney, Isabelle
Sibille, Brigitte
Le Menn, Gwenaëlle
Chinetti, Giulia
Neels, Jaap G.
Rousseau, Anne-Sophie
author_sort Le Garf, Sébastien
collection PubMed
description Regular aerobic exercise, independently of weight loss, improves metabolic and anti-inflammatory states, and can be regarded as beneficial in counteracting obesity-induced low-grade inflammation. However, it is still unknown how exercise alters immunometabolism in a context of dietary changes. Agonists of the Peroxisome Proliferator Activated-Receptor beta/delta (PPARβ/δ) have been studied this last decade as “exercise-mimetics”, which are potential therapies for metabolic diseases. In this study, we address the question of whether PPARβ/δ agonist treatment would improve the immunometabolic changes induced by exercise in diet-induced obese female mice, having switched from a high fat diet to a normal diet. 24 mice were assigned to groups according to an 8-week exercise training program and/or an 8-week treatment with 3 mg/kg/day of GW0742, a PPARβ/δ agonist. Our results show metabolic changes of peripheral lymphoid tissues with PPARβ/δ agonist (increase in fatty acid oxidation gene expression) or exercise (increase in AMPK activity) and a potentiating effect of the combination of both on the percentage of anti-inflammatory Foxp3+ T cells. Those effects are associated with a decreased visceral adipose tissue mass and skeletal muscle inflammation (TNF-α, Il-6, Il-1β mRNA level), an increase in skeletal muscle oxidative capacities (citrate synthase activity, endurance capacity), and insulin sensitivity. We conclude that a therapeutic approach targeting the PPARβ/δ pathway would improve obesity treatment.
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spelling pubmed-68293332019-11-18 Complementary Immunometabolic Effects of Exercise and PPARβ/δ Agonist in the Context of Diet-Induced Weight Loss in Obese Female Mice Le Garf, Sébastien Murdaca, Joseph Mothe-Satney, Isabelle Sibille, Brigitte Le Menn, Gwenaëlle Chinetti, Giulia Neels, Jaap G. Rousseau, Anne-Sophie Int J Mol Sci Article Regular aerobic exercise, independently of weight loss, improves metabolic and anti-inflammatory states, and can be regarded as beneficial in counteracting obesity-induced low-grade inflammation. However, it is still unknown how exercise alters immunometabolism in a context of dietary changes. Agonists of the Peroxisome Proliferator Activated-Receptor beta/delta (PPARβ/δ) have been studied this last decade as “exercise-mimetics”, which are potential therapies for metabolic diseases. In this study, we address the question of whether PPARβ/δ agonist treatment would improve the immunometabolic changes induced by exercise in diet-induced obese female mice, having switched from a high fat diet to a normal diet. 24 mice were assigned to groups according to an 8-week exercise training program and/or an 8-week treatment with 3 mg/kg/day of GW0742, a PPARβ/δ agonist. Our results show metabolic changes of peripheral lymphoid tissues with PPARβ/δ agonist (increase in fatty acid oxidation gene expression) or exercise (increase in AMPK activity) and a potentiating effect of the combination of both on the percentage of anti-inflammatory Foxp3+ T cells. Those effects are associated with a decreased visceral adipose tissue mass and skeletal muscle inflammation (TNF-α, Il-6, Il-1β mRNA level), an increase in skeletal muscle oxidative capacities (citrate synthase activity, endurance capacity), and insulin sensitivity. We conclude that a therapeutic approach targeting the PPARβ/δ pathway would improve obesity treatment. MDPI 2019-10-19 /pmc/articles/PMC6829333/ /pubmed/31635041 http://dx.doi.org/10.3390/ijms20205182 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Le Garf, Sébastien
Murdaca, Joseph
Mothe-Satney, Isabelle
Sibille, Brigitte
Le Menn, Gwenaëlle
Chinetti, Giulia
Neels, Jaap G.
Rousseau, Anne-Sophie
Complementary Immunometabolic Effects of Exercise and PPARβ/δ Agonist in the Context of Diet-Induced Weight Loss in Obese Female Mice
title Complementary Immunometabolic Effects of Exercise and PPARβ/δ Agonist in the Context of Diet-Induced Weight Loss in Obese Female Mice
title_full Complementary Immunometabolic Effects of Exercise and PPARβ/δ Agonist in the Context of Diet-Induced Weight Loss in Obese Female Mice
title_fullStr Complementary Immunometabolic Effects of Exercise and PPARβ/δ Agonist in the Context of Diet-Induced Weight Loss in Obese Female Mice
title_full_unstemmed Complementary Immunometabolic Effects of Exercise and PPARβ/δ Agonist in the Context of Diet-Induced Weight Loss in Obese Female Mice
title_short Complementary Immunometabolic Effects of Exercise and PPARβ/δ Agonist in the Context of Diet-Induced Weight Loss in Obese Female Mice
title_sort complementary immunometabolic effects of exercise and pparβ/δ agonist in the context of diet-induced weight loss in obese female mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829333/
https://www.ncbi.nlm.nih.gov/pubmed/31635041
http://dx.doi.org/10.3390/ijms20205182
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