Role of APD-Ribosylation in Bone Health and Disease

The transfer of adenosine diphosphate (ADP)-ribose unit(s) from nicotinamide adenine dinucleotide (NAD(+)) to acceptor proteins is known as ADP-ribosylation. This post-translational modification (PTM) unavoidably alters protein functions and signaling networks, thereby impacting cell behaviors and t...

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Detalles Bibliográficos
Autores principales: Wang, Chun, Mbalaviele, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829334/
https://www.ncbi.nlm.nih.gov/pubmed/31590342
http://dx.doi.org/10.3390/cells8101201
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author Wang, Chun
Mbalaviele, Gabriel
author_facet Wang, Chun
Mbalaviele, Gabriel
author_sort Wang, Chun
collection PubMed
description The transfer of adenosine diphosphate (ADP)-ribose unit(s) from nicotinamide adenine dinucleotide (NAD(+)) to acceptor proteins is known as ADP-ribosylation. This post-translational modification (PTM) unavoidably alters protein functions and signaling networks, thereby impacting cell behaviors and tissue outcomes. As a ubiquitous mechanism, ADP-ribosylation affects multiple tissues, including bones, as abnormal ADP-ribosylation compromises bone development and remodeling. In this review, we describe the effects of ADP-ribosylation in bone development and maintenance, and highlight the underlying mechanisms.
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spelling pubmed-68293342019-11-18 Role of APD-Ribosylation in Bone Health and Disease Wang, Chun Mbalaviele, Gabriel Cells Review The transfer of adenosine diphosphate (ADP)-ribose unit(s) from nicotinamide adenine dinucleotide (NAD(+)) to acceptor proteins is known as ADP-ribosylation. This post-translational modification (PTM) unavoidably alters protein functions and signaling networks, thereby impacting cell behaviors and tissue outcomes. As a ubiquitous mechanism, ADP-ribosylation affects multiple tissues, including bones, as abnormal ADP-ribosylation compromises bone development and remodeling. In this review, we describe the effects of ADP-ribosylation in bone development and maintenance, and highlight the underlying mechanisms. MDPI 2019-10-05 /pmc/articles/PMC6829334/ /pubmed/31590342 http://dx.doi.org/10.3390/cells8101201 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Chun
Mbalaviele, Gabriel
Role of APD-Ribosylation in Bone Health and Disease
title Role of APD-Ribosylation in Bone Health and Disease
title_full Role of APD-Ribosylation in Bone Health and Disease
title_fullStr Role of APD-Ribosylation in Bone Health and Disease
title_full_unstemmed Role of APD-Ribosylation in Bone Health and Disease
title_short Role of APD-Ribosylation in Bone Health and Disease
title_sort role of apd-ribosylation in bone health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829334/
https://www.ncbi.nlm.nih.gov/pubmed/31590342
http://dx.doi.org/10.3390/cells8101201
work_keys_str_mv AT wangchun roleofapdribosylationinbonehealthanddisease
AT mbalavielegabriel roleofapdribosylationinbonehealthanddisease

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