PGC-1α Suppresses the Activation of TGF-β/Smad Signaling via Targeting TGFβRI Downregulation by let-7b/c Upregulation

TGF-β/Smad signaling is a major pathway in progressive fibrotic processes, and further studies on the molecular mechanisms of TGF-β/Smad signaling are still needed for their therapeutic targeting. Recently, peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) was shown to improve ren...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Hoon-In, Park, Jung Sun, Kim, Dong-Hyun, Kim, Chang Seong, Bae, Eun Hui, Ma, Seong Kwon, Kim, Soo Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829475/
https://www.ncbi.nlm.nih.gov/pubmed/31614978
http://dx.doi.org/10.3390/ijms20205084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829475/
https://www.ncbi.nlm.nih.gov/pubmed/31614978
http://dx.doi.org/10.3390/ijms20205084

Ejemplares similares