Silencing Lysine-Specific Histone Demethylase 1 (LSD1) Causes Increased HP1-Positive Chromatin, Stimulation of DNA Repair Processes, and Dysregulation of Proliferation by Chk1 Phosphorylation in Human Endothelial Cells

The methylation of histone lysine residues modifies chromatin conformation and regulates the expression of genes implicated in cell metabolism. Lysine-specific demethylase 1 (LSD1) is a flavin-dependent monoamine oxidase that can demethylate mono- and dimethylated histone lysines 4 and 9 (H3K4 and H...

Descripción completa

Detalles Bibliográficos
Autores principales: Wojtala, Martyna, Dąbek, Arkadiusz, Rybaczek, Dorota, Śliwińska, Agnieszka, Świderska, Ewa, Słapek, Katarzyna, El-Osta, Assam, Balcerczyk, Aneta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829479/
https://www.ncbi.nlm.nih.gov/pubmed/31591366
http://dx.doi.org/10.3390/cells8101212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829479/
https://www.ncbi.nlm.nih.gov/pubmed/31591366
http://dx.doi.org/10.3390/cells8101212

Ejemplares similares