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Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus
The micronutrients vitamins B9 and B12 act as methyl donors in the one-carbon metabolism involved in transmethylation reactions which critically influence epigenetic mechanisms and gene expression. Both vitamins are essential for proper development, and their deficiency during pregnancy has been ass...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829491/ https://www.ncbi.nlm.nih.gov/pubmed/31615150 http://dx.doi.org/10.3390/ijms20205097 |
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author | Saber Cherif, Lynda Pourié, Grégory Geoffroy, Andréa Julien, Amélia Helle, Déborah Robert, Aurélie Umoret, Rémy Guéant, Jean-Louis Bossenmeyer-Pourié, Carine Daval, Jean-Luc |
author_facet | Saber Cherif, Lynda Pourié, Grégory Geoffroy, Andréa Julien, Amélia Helle, Déborah Robert, Aurélie Umoret, Rémy Guéant, Jean-Louis Bossenmeyer-Pourié, Carine Daval, Jean-Luc |
author_sort | Saber Cherif, Lynda |
collection | PubMed |
description | The micronutrients vitamins B9 and B12 act as methyl donors in the one-carbon metabolism involved in transmethylation reactions which critically influence epigenetic mechanisms and gene expression. Both vitamins are essential for proper development, and their deficiency during pregnancy has been associated with a wide range of disorders, including persisting growth retardation. Energy homeostasis and feeding are centrally regulated by the hypothalamus which integrates peripheral signals and acts through several orexigenic and anorexigenic mediators. We studied this regulating system in a rat model of methyl donor deficiency during gestation and lactation. At weaning, a predominance of the anorexigenic pathway was observed in deficient pups, with increased plasma peptide YY and increased hypothalamic pro-opiomelanocortin (POMC) mRNA, in line with abnormal leptin, ghrelin, and insulin secretion and/or signaling during critical periods of fetal and/or postnatal development of the hypothalamus. These results suggest that early methyl donor deficiency can affect the development and function of energy balance circuits, resulting in growth and weight deficits. Maternal administration of folic acid (3 mg/kg/day) during the perinatal period tended to rectify peripheral metabolic signaling and central neuropeptide and receptor expression, leading to reduced growth retardation. |
format | Online Article Text |
id | pubmed-6829491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68294912019-11-18 Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus Saber Cherif, Lynda Pourié, Grégory Geoffroy, Andréa Julien, Amélia Helle, Déborah Robert, Aurélie Umoret, Rémy Guéant, Jean-Louis Bossenmeyer-Pourié, Carine Daval, Jean-Luc Int J Mol Sci Article The micronutrients vitamins B9 and B12 act as methyl donors in the one-carbon metabolism involved in transmethylation reactions which critically influence epigenetic mechanisms and gene expression. Both vitamins are essential for proper development, and their deficiency during pregnancy has been associated with a wide range of disorders, including persisting growth retardation. Energy homeostasis and feeding are centrally regulated by the hypothalamus which integrates peripheral signals and acts through several orexigenic and anorexigenic mediators. We studied this regulating system in a rat model of methyl donor deficiency during gestation and lactation. At weaning, a predominance of the anorexigenic pathway was observed in deficient pups, with increased plasma peptide YY and increased hypothalamic pro-opiomelanocortin (POMC) mRNA, in line with abnormal leptin, ghrelin, and insulin secretion and/or signaling during critical periods of fetal and/or postnatal development of the hypothalamus. These results suggest that early methyl donor deficiency can affect the development and function of energy balance circuits, resulting in growth and weight deficits. Maternal administration of folic acid (3 mg/kg/day) during the perinatal period tended to rectify peripheral metabolic signaling and central neuropeptide and receptor expression, leading to reduced growth retardation. MDPI 2019-10-14 /pmc/articles/PMC6829491/ /pubmed/31615150 http://dx.doi.org/10.3390/ijms20205097 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Saber Cherif, Lynda Pourié, Grégory Geoffroy, Andréa Julien, Amélia Helle, Déborah Robert, Aurélie Umoret, Rémy Guéant, Jean-Louis Bossenmeyer-Pourié, Carine Daval, Jean-Luc Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus |
title | Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus |
title_full | Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus |
title_fullStr | Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus |
title_full_unstemmed | Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus |
title_short | Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus |
title_sort | methyl donor deficiency during gestation and lactation in the rat affects the expression of neuropeptides and related receptors in the hypothalamus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829491/ https://www.ncbi.nlm.nih.gov/pubmed/31615150 http://dx.doi.org/10.3390/ijms20205097 |
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