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Inhibition of Dephosphorylation of Dolichyl Diphosphate Alters the Synthesis of Dolichol and Hinders Protein N-Glycosylation and Morphological Transitions in Candida albicans
The essential role of dolichyl phosphate (DolP) as a carbohydrate carrier during protein N-glycosylation is well established. The cellular pool of DolP is derived from de novo synthesis in the dolichol branch of the mevalonate pathway and from recycling of DolPP after each cycle of N-glycosylation,...
Autores principales: | Janik, Anna, Niewiadomska, Monika, Perlińska-Lenart, Urszula, Lenart, Jacek, Kołakowski, Damian, Skorupińska-Tudek, Karolina, Swiezewska, Ewa, Kruszewska, Joanna S., Palamarczyk, Grażyna |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829516/ https://www.ncbi.nlm.nih.gov/pubmed/31614738 http://dx.doi.org/10.3390/ijms20205067 |
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