Cargando…

N-Glycosylation of TREK-1/hK(2P)2.1 Two-Pore-Domain Potassium (K(2P)) Channels

Mechanosensitive hTREK-1 two-pore-domain potassium (hK(2P)2.1) channels give rise to background currents that control cellular excitability. Recently, TREK-1 currents have been linked to the regulation of cardiac rhythm as well as to hypertrophy and fibrosis. Even though the pharmacological and biop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wiedmann, Felix, Schlund, Daniel, Faustino, Francisco, Kraft, Manuel, Ratte, Antonius, Thomas, Dierk, Katus, Hugo A., Schmidt, Constanze
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829520/ https://www.ncbi.nlm.nih.gov/pubmed/31635148 http://dx.doi.org/10.3390/ijms20205193

Ejemplares similares

N-glycosylation–dependent regulation of hK(2P)17.1 currents
por: Wiedmann, Felix, et al.
Publicado: (2019)

Antiarrhythmic Properties of Ranolazine: Inhibition of Atrial Fibrillation Associated TASK-1 Potassium Channels
por: Ratte, Antonius, et al.
Publicado: (2019)

Two-Pore-Domain Potassium (K(2P)-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes
por: Wiedmann, Felix, et al.
Publicado: (2021)

Prognostic significance of the TREK-1 K2P potassium channels in prostate cancer
por: Zhang, Gui-Ming, et al.
Publicado: (2015)

Conformational plasticity of NaK2K and TREK2 potassium channel selectivity filters
por: Matamoros, Marcos, et al.
Publicado: (2023)

The effects of stretch activation on ionic selectivity of the TREK-2 K2P K(+) channel
por: Nematian-Ardestani, Ehsan, et al.
Publicado: (2017)

K(2P)2.1 (TREK-1) potassium channel activation protects against hyperoxia-induced lung injury
por: Zyrianova, Tatiana, et al.
Publicado: (2020)

Effects of ionic strength on gating and permeation of TREK-2 K2P channels
por: Conrad, Linus J., et al.
Publicado: (2021)

Pharmacologically reversible, loss of function mutations in the TM2 and TM4 inner pore helices of TREK-1 K2P channels
por: Al-Moubarak, Ehab, et al.
Publicado: (2019)

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel
por: Aryal, Prafulla, et al.
Publicado: (2017)

Altered Expression of Two-Pore Domain Potassium (K(2P)) Channels in Cancer
por: Williams, Sarah, et al.
Publicado: (2013)

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states
por: McClenaghan, Conor, et al.
Publicado: (2016)

Activation of K(2)P channel–TREK1 mediates the neuroprotection induced by sevoflurane preconditioning
por: Tong, L., et al.
Publicado: (2014)

A role for two-pore potassium (K2P) channels in endometrial epithelial function
por: Patel, Suraj K, et al.
Publicado: (2013)

Transition between conformational states of the TREK-1 K2P channel promoted by interaction with PIP(2)
por: Panasawatwong, Adisorn, et al.
Publicado: (2022)

Two‐Pore K(+) Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability
por: Unudurthi, Sathya D., et al.
Publicado: (2016)

The 2-Pore Domain Potassium Channel TREK-1 Regulates Stretch-Induced Detachment of Alveolar Epithelial Cells
por: Roan, Esra, et al.
Publicado: (2014)

Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine and CEN-092
por: Walsh, Yvonne, et al.
Publicado: (2021)

Pharmacologic TWIK‐Related Acid‐Sensitive K+ Channel (TASK‐1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model
por: Wiedmann, Felix, et al.
Publicado: (2020)

Roles of kallikrein-2 biomarkers (free-hK2 and pro-hK2) for predicting prostate cancer progression-free survival
por: Guerrico, Anatilde Gonzalez, et al.
Publicado: (2017)

Endocytosis as a mode to regulate functional expression of two-pore domain potassium (K(2P)) channels
por: O’Kelly, Ita
Publicado: (2014)

A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel
por: Aryal, Prafulla, et al.
Publicado: (2014)

A “Target Class” Screen to Identify Activators of Two-Pore Domain Potassium (K2P) Channels
por: McCoull, David, et al.
Publicado: (2020)

Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains
por: Bagriantsev, Sviatoslav N, et al.
Publicado: (2012)

K(2P)2.1(TREK-1):activator complexes reveal a cryptic selectivity filter binding site
por: Lolicato, Marco, et al.
Publicado: (2017)

The pore structure and gating mechanism of K2P channels
por: Piechotta, Paula L, et al.
Publicado: (2011)

Intersubunit Concerted Cooperative and cis-Type Mechanisms Modulate Allosteric Gating in Two-Pore-Domain Potassium Channel TREK-2
por: Zhuo, Ren-Gong, et al.
Publicado: (2016)

Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina
por: Hughes, Steven, et al.
Publicado: (2017)

Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate
por: Proks, Peter, et al.
Publicado: (2021)

‘C-type’ closed state and gating mechanisms of K2P channels revealed by conformational changes of the TREK-1 channel
por: Zhang, Qiansen, et al.
Publicado: (2022)

The response of the tandem pore potassium channel TASK-3 (K(2P)9.1) to voltage: gating at the cytoplasmic mouth
por: Ashmole, I, et al.
Publicado: (2009)

Characterization of temperature-sensitive leak K(+) currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats
por: Viatchenko-Karpinski, Viacheslav, et al.
Publicado: (2018)

The Prostacyclin Analogue, Treprostinil, Used in the Treatment of Pulmonary Arterial Hypertension, is a Potent Antagonist of TREK-1 and TREK-2 Potassium Channels
por: Cunningham, Kevin P., et al.
Publicado: (2021)

Activation of TREK-1, but Not TREK-2, Channel by Mood Stabilizers
por: Kim, Eun-Jin, et al.
Publicado: (2017)

Trigger-Specific Remodeling of K(Ca)2 Potassium Channels in Models of Atrial Fibrillation
por: Rahm, Ann-Kathrin, et al.
Publicado: (2021)

Structural Insights into the Mechanisms and Pharmacology of K(2P) Potassium Channels
por: Natale, Andrew M., et al.
Publicado: (2021)

Contribution of K2P Potassium Channels to Cardiac Physiology and Pathophysiology
por: Herrera-Pérez, Salvador, et al.
Publicado: (2021)

Two-Pore-Domain Potassium Channel TREK–1 Mediates Pulmonary Fibrosis through Macrophage M2 Polarization and by Direct Promotion of Fibroblast Differentiation
por: Zhang, Yunna, et al.
Publicado: (2023)

PIP(2) Mediated Inhibition of TREK Potassium Currents by Bradykinin in Mouse Sympathetic Neurons
por: Rivas-Ramírez, Paula, et al.
Publicado: (2020)

Two pore domain potassium channels in cerebral ischemia: a focus on K(2P)9.1 (TASK3, KCNK9)
por: Ehling, Petra, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_mh26qi7kq91frb6rbk9dv7npev