Cargando…

Low temperature traps myosin motors of mammalian muscle in a refractory state that prevents activation

Myosin motors in the thick filament of resting striated (skeletal and cardiac) muscle are trapped in an OFF state, in which the motors are packed in helical tracks on the filament surface, inhibiting their interactions with actin and utilization of ATP. To investigate the structural changes induced...

Descripción completa

Detalles Bibliográficos
Autores principales:	Caremani, Marco, Brunello, Elisabetta, Linari, Marco, Fusi, Luca, Irving, Thomas C., Gore, David, Piazzesi, Gabriella, Irving, Malcolm, Lombardi, Vincenzo, Reconditi, Massimo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829559/ https://www.ncbi.nlm.nih.gov/pubmed/31554652 http://dx.doi.org/10.1085/jgp.201912424

Ejemplares similares

Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle
por: Caremani, Marco, et al.
Publicado: (2023)

Myosin motors that cannot bind actin leave their folded OFF state on activation of skeletal muscle
por: Reconditi, Massimo, et al.
Publicado: (2021)

Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing
por: Caremani, Marco, et al.
Publicado: (2021)

The force of the myosin motor sets cooperativity in thin filament activation of skeletal muscles
por: Caremani, Marco, et al.
Publicado: (2022)

Thick Filament Mechano-Sensing in Skeletal and Cardiac Muscles: A Common Mechanism Able to Adapt the Energetic Cost of the Contraction to the Task
por: Piazzesi, Gabriella, et al.
Publicado: (2018)

Matching Mechanics and Energetics of Muscle Contraction Suggests Unconventional Chemomechanical Coupling during the Actin–Myosin Interaction
por: Pertici, Irene, et al.
Publicado: (2023)

Inotropic interventions do not change the resting state of myosin motors during cardiac diastole
por: Caremani, Marco, et al.
Publicado: (2019)

Anisotropic Elasticity of the Myosin Motor in Muscle
por: Caremani, Marco, et al.
Publicado: (2022)

Titin activates myosin filaments in skeletal muscle by switching from an extensible spring to a mechanical rectifier
por: Squarci, Caterina, et al.
Publicado: (2023)

Mechanics of myosin function in white muscle fibres of the dogfish, Scyliorhinus canicula
por: Park-Holohan, S, et al.
Publicado: (2012)

Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil
por: Governali, Serena, et al.
Publicado: (2020)

Activation of the myosin motors in fast‐twitch muscle of the mouse is controlled by mechano‐sensing in the myosin filaments
por: Hill, Cameron, et al.
Publicado: (2022)

Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle
por: Hill, Cameron, et al.
Publicado: (2021)

Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation
por: Ovejero, Jesus G., et al.
Publicado: (2022)

Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing
por: Park-Holohan, So-Jin, et al.
Publicado: (2021)

Myosin filament-based regulation of the dynamics of contraction in heart muscle
por: Brunello, Elisabetta, et al.
Publicado: (2020)

The Conformation of Myosin Heads in Relaxed Skeletal Muscle: Implications for Myosin-Based Regulation
por: Fusi, Luca, et al.
Publicado: (2015)

Activation of skeletal muscle is controlled by a dual-filament mechano-sensing mechanism
por: Brunello, Elisabetta, et al.
Publicado: (2023)

The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle
por: Kampourakis, Thomas, et al.
Publicado: (2021)

Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle
por: Kampourakis, Thomas, et al.
Publicado: (2015)

Editorial to the Special Issue “Molecular Motors: From Single Molecules to Cooperative and Regulatory Mechanisms In Vivo”
por: Capitanio, Marco, et al.
Publicado: (2022)

Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle
por: Fusi, L., et al.
Publicado: (2016)

Orientation of the N- and C-Terminal Lobes of the Myosin Regulatory Light Chain in Cardiac Muscle
por: Kampourakis, Thomas, et al.
Publicado: (2015)

A new spring for titin
por: Brunello, Elisabetta, et al.
Publicado: (2020)

Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament
por: Kampourakis, Thomas, et al.
Publicado: (2017)

Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle
por: Kampourakis, Thomas, et al.
Publicado: (2018)

Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I
por: Sevrieva, Ivanka R., et al.
Publicado: (2020)

Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice
por: Yuan, Chen-Ching, et al.
Publicado: (2018)

Porcine myosin-VI: characterization of a new mammalian unconventional myosin
Publicado: (1994)

Structural and functional effects of myosin-binding protein-C phosphorylation in heart muscle are not mimicked by serine-to-aspartate substitutions
por: Kampourakis, Thomas, et al.
Publicado: (2018)

Site-specific phosphorylation of myosin binding protein-C coordinates thin and thick filament activation in cardiac muscle
por: Ponnam, Saraswathi, et al.
Publicado: (2019)

Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle
por: Ma, Weikang, et al.
Publicado: (2018)

In situ FRET-based localization of the N terminus of myosin binding protein-C in heart muscle cells
por: Chandler, Jessica, et al.
Publicado: (2023)

Cardiac myosin filaments are directly regulated by calcium
por: Ma, Weikang, et al.
Publicado: (2022)

Phosphorylation-dependent interactions of myosin-binding protein C and troponin coordinate the myofilament response to protein kinase A
por: Sevrieva, Ivanka R., et al.
Publicado: (2022)

A protocol for single molecule imaging and tracking of processive myosin motors
por: Gardini, Lucia, et al.
Publicado: (2019)

CATALASE REQUIREMENT FOR MAMMALIAN CELLS IN CULTURE
por: Lieberman, Irving, et al.
Publicado: (1958)

The myosin X motor is optimized for movement on actin bundles
por: Ropars, Virginie, et al.
Publicado: (2016)

Convergent evolutionary pathways toward energy saving in muscle?
por: Reconditi, Massimo
Publicado: (2021)

Tissue distribution and subcellular localization of mammalian myosin I
Publicado: (1992)

Cannot write session to /tmp/vufind_sessions/sess_m70t1vaillb4kd3f8o2ktfkmh2