Angiotensin II Influences Pre-mRNA Splicing Regulation by Enhancing RBM20 Transcription Through Activation of the MAPK/ELK1 Signaling Pathway

RNA binding motif 20 (RBM20) is a key regulator of pre-mRNA splicing of titin and other genes that are associated with cardiac diseases. Hormones, like insulin, triiodothyronine (T3), and angiotensin II (Ang II), can regulate gene-splicing through RBM20, but the detailed mechanism remains unclear. T...

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Detalles Bibliográficos
Autores principales: Cai, Hanfang, Zhu, Chaoqun, Chen, Zhilong, Maimaiti, Rexiati, Sun, Mingming, McCormick, Richard J., Lan, Xianyong, Chen, Hong, Guo, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829565/
https://www.ncbi.nlm.nih.gov/pubmed/31614708
http://dx.doi.org/10.3390/ijms20205059

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