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Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model

Chronic activation of brain innate immunity is a prominent feature of Alzheimer’s disease (AD) and primary tauopathies. However, to what degree innate immunity contributes to neurodegeneration as compared with pathological protein-induced neurotoxicity, and the requirement of a particular glial cell...

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Detalles Bibliográficos
Autores principales:	Shi, Yang, Manis, Melissa, Long, Justin, Wang, Kairuo, Sullivan, Patrick M., Remolina Serrano, Javier, Hoyle, Rosa, Holtzman, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829593/ https://www.ncbi.nlm.nih.gov/pubmed/31601677 http://dx.doi.org/10.1084/jem.20190980

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