C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner

Dysfunctional autophagy or ubiquitin-proteasome system (UPS) are suggested to underlie abnormal protein aggregation in neurodegenerative diseases. Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS)-associated C9orf72 is implicated in autophagy, but whether it activates or inhibits...

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Detalles Bibliográficos
Autores principales: Leskelä, Stina, Huber, Nadine, Rostalski, Hannah, Natunen, Teemu, Remes, Anne M., Takalo, Mari, Hiltunen, Mikko, Haapasalo, Annakaisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829620/
https://www.ncbi.nlm.nih.gov/pubmed/31658762
http://dx.doi.org/10.3390/cells8101233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829620/
https://www.ncbi.nlm.nih.gov/pubmed/31658762
http://dx.doi.org/10.3390/cells8101233

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