LIS1 regulates cargo-adapter–mediated activation of dynein by overcoming its autoinhibition in vivo

Deficiency of the LIS1 protein causes lissencephaly, a brain developmental disorder. Although LIS1 binds the microtubule motor cytoplasmic dynein and has been linked to dynein function in many experimental systems, its mechanism of action remains unclear. Here, we revealed its function in cargo-adap...

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Detalles Bibliográficos
Autores principales: Qiu, Rongde, Zhang, Jun, Xiang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829669/
https://www.ncbi.nlm.nih.gov/pubmed/31562232
http://dx.doi.org/10.1083/jcb.201905178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829669/
https://www.ncbi.nlm.nih.gov/pubmed/31562232
http://dx.doi.org/10.1083/jcb.201905178

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