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Ancestral roles of the Fam20C family of secreted protein kinases revealed in C. elegans

Fam20C is a secreted protein kinase mutated in Raine syndrome, a human skeletal disorder. In vertebrates, bone and enamel proteins are major Fam20C substrates. However, Fam20 kinases are conserved in invertebrates lacking bone and enamel, suggesting other ancestral functions. We show that FAMK-1, th...

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Detalles Bibliográficos
Autores principales:	Gerson-Gurwitz, Adina, Worby, Carolyn A., Lee, Kian-Yong, Khaliullin, Renat, Bouffard, Jeff, Cheerambathur, Dhanya, Oegema, Karen, Cram, Erin J., Dixon, Jack E., Desai, Arshad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829671/ https://www.ncbi.nlm.nih.gov/pubmed/31541016 http://dx.doi.org/10.1083/jcb.201807041

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