ALDH-Dependent Glycolytic Activation Mediates Stemness and Paclitaxel Resistance in Patient-Derived Spheroid Models of Uterine Endometrial Cancer

Uterine endometrial cancer is associated with poor survival outcomes in patients with advanced-stage disease. Here, we developed a three-dimensional cell cultivation method of endometrioid cancer stem-like cells with high aldehyde dehydrogenase (ALDH) activity from clinical specimens. ALDH inhibitio...

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Detalles Bibliográficos
Autores principales: Mori, Yutaro, Yamawaki, Kaoru, Ishiguro, Tatsuya, Yoshihara, Kosuke, Ueda, Haruka, Sato, Ai, Ohata, Hirokazu, Yoshida, Yohko, Minamino, Tohru, Okamoto, Koji, Enomoto, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829754/
https://www.ncbi.nlm.nih.gov/pubmed/31564647
http://dx.doi.org/10.1016/j.stemcr.2019.08.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829754/
https://www.ncbi.nlm.nih.gov/pubmed/31564647
http://dx.doi.org/10.1016/j.stemcr.2019.08.015

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