Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs

Mutations in the microtubule-associated protein tau (MAPT) gene are known to cause familial frontotemporal dementia (FTD). The R406W tau mutation is a unique missense mutation whose patients have been reported to exhibit Alzheimer’s disease (AD)-like phenotypes rather than the more typical FTD pheno...

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Detalles Bibliográficos
Autores principales: Nakamura, Mari, Shiozawa, Seiji, Tsuboi, Daisuke, Amano, Mutsuki, Watanabe, Hirotaka, Maeda, Sumihiro, Kimura, Taeko, Yoshimatsu, Sho, Kisa, Fumihiko, Karch, Celeste M., Miyasaka, Tomohiro, Takashima, Akihiko, Sahara, Naruhiko, Hisanaga, Shin-ichi, Ikeuchi, Takeshi, Kaibuchi, Kozo, Okano, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829766/
https://www.ncbi.nlm.nih.gov/pubmed/31543469
http://dx.doi.org/10.1016/j.stemcr.2019.08.011

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