Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy

Nuclear-cytoplasmic shuttling is a highly regulated and complex process, which involves both proteins and nucleic acids. Changes in cellular compartmentalization of various proteins, including oncogenes and tumor suppressors, affect cellular behavior, promoting or inhibiting proliferation, apoptosis...

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Detalles Bibliográficos
Autores principales: Carrà, Giovanna, Russo, Isabella, Guerrasio, Angelo, Morotti, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830087/
https://www.ncbi.nlm.nih.gov/pubmed/31614958
http://dx.doi.org/10.3390/cells8101248
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author Carrà, Giovanna
Russo, Isabella
Guerrasio, Angelo
Morotti, Alessandro
author_facet Carrà, Giovanna
Russo, Isabella
Guerrasio, Angelo
Morotti, Alessandro
author_sort Carrà, Giovanna
collection PubMed
description Nuclear-cytoplasmic shuttling is a highly regulated and complex process, which involves both proteins and nucleic acids. Changes in cellular compartmentalization of various proteins, including oncogenes and tumor suppressors, affect cellular behavior, promoting or inhibiting proliferation, apoptosis and sensitivity to therapies. In this review, we will recapitulate the role of various shuttling components in Chronic Myeloid Leukemia and we will provide insights on the potential role of shuttling proteins as therapeutic targets.
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spelling pubmed-68300872019-11-18 Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy Carrà, Giovanna Russo, Isabella Guerrasio, Angelo Morotti, Alessandro Cells Review Nuclear-cytoplasmic shuttling is a highly regulated and complex process, which involves both proteins and nucleic acids. Changes in cellular compartmentalization of various proteins, including oncogenes and tumor suppressors, affect cellular behavior, promoting or inhibiting proliferation, apoptosis and sensitivity to therapies. In this review, we will recapitulate the role of various shuttling components in Chronic Myeloid Leukemia and we will provide insights on the potential role of shuttling proteins as therapeutic targets. MDPI 2019-10-14 /pmc/articles/PMC6830087/ /pubmed/31614958 http://dx.doi.org/10.3390/cells8101248 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Carrà, Giovanna
Russo, Isabella
Guerrasio, Angelo
Morotti, Alessandro
Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy
title Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy
title_full Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy
title_fullStr Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy
title_full_unstemmed Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy
title_short Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy
title_sort nuclear-cytoplasmic shuttling in chronic myeloid leukemia: implications in leukemia maintenance and therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830087/
https://www.ncbi.nlm.nih.gov/pubmed/31614958
http://dx.doi.org/10.3390/cells8101248
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