Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018

The growing multidrug-resistant Neisseria gonorrhoeae is a serious global threat to gonococcal therapy. During 2017–2018, we identified a rare multidrug-resistant (ceftriaxone and azithromycin) strain (GC250) and four strains (GC185, GC195, GC196 and GC249) with both resistance to ceftriaxone and de...

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Autores principales: Yuan, Qianqin, Li, Yamei, Xiu, Leshan, Zhang, Chi, Fu, Yaoyang, Jiang, Chuanhao, Tang, Lingli, Peng, Junping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830194/
https://www.ncbi.nlm.nih.gov/pubmed/31661379
http://dx.doi.org/10.1080/22221751.2019.1681242
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author Yuan, Qianqin
Li, Yamei
Xiu, Leshan
Zhang, Chi
Fu, Yaoyang
Jiang, Chuanhao
Tang, Lingli
Peng, Junping
author_facet Yuan, Qianqin
Li, Yamei
Xiu, Leshan
Zhang, Chi
Fu, Yaoyang
Jiang, Chuanhao
Tang, Lingli
Peng, Junping
author_sort Yuan, Qianqin
collection PubMed
description The growing multidrug-resistant Neisseria gonorrhoeae is a serious global threat to gonococcal therapy. During 2017–2018, we identified a rare multidrug-resistant (ceftriaxone and azithromycin) strain (GC250) and four strains (GC185, GC195, GC196 and GC249) with both resistance to ceftriaxone and decreased susceptibility to azithromycin. All strains belonged to NG-STAR ST1143, including the mosaic penA-60.001, which is closely related to ceftriaxone resistance. The characterization of antimicrobial resistance (AMR) determinants and phylogenetic analysis showed these five strains were closely related to internationally spreading ceftriaxone-resistant N. gonorrhoeae FC428, but with higher azithromycin MIC. Findings here demonstrated that this clone not only initiated clonal expansion in China, but acquired azithromycin resistance.
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spelling pubmed-68301942019-11-07 Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018 Yuan, Qianqin Li, Yamei Xiu, Leshan Zhang, Chi Fu, Yaoyang Jiang, Chuanhao Tang, Lingli Peng, Junping Emerg Microbes Infect Letter The growing multidrug-resistant Neisseria gonorrhoeae is a serious global threat to gonococcal therapy. During 2017–2018, we identified a rare multidrug-resistant (ceftriaxone and azithromycin) strain (GC250) and four strains (GC185, GC195, GC196 and GC249) with both resistance to ceftriaxone and decreased susceptibility to azithromycin. All strains belonged to NG-STAR ST1143, including the mosaic penA-60.001, which is closely related to ceftriaxone resistance. The characterization of antimicrobial resistance (AMR) determinants and phylogenetic analysis showed these five strains were closely related to internationally spreading ceftriaxone-resistant N. gonorrhoeae FC428, but with higher azithromycin MIC. Findings here demonstrated that this clone not only initiated clonal expansion in China, but acquired azithromycin resistance. Taylor & Francis 2019-10-29 /pmc/articles/PMC6830194/ /pubmed/31661379 http://dx.doi.org/10.1080/22221751.2019.1681242 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter
Yuan, Qianqin
Li, Yamei
Xiu, Leshan
Zhang, Chi
Fu, Yaoyang
Jiang, Chuanhao
Tang, Lingli
Peng, Junping
Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018
title Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018
title_full Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018
title_fullStr Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018
title_full_unstemmed Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018
title_short Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018
title_sort identification of multidrug-resistant neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, china, 2017–2018
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830194/
https://www.ncbi.nlm.nih.gov/pubmed/31661379
http://dx.doi.org/10.1080/22221751.2019.1681242
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