High-throughput structures of protein–ligand complexes at room temperature using serial femtosecond crystallography

High-throughput X-ray crystal structures of protein–ligand complexes are critical to pharmaceutical drug development. However, cryocooling of crystals and X-ray radiation damage may distort the observed ligand binding. Serial femtosecond crystallography (SFX) using X-ray free-electron lasers (XFELs)...

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Detalles Bibliográficos
Autores principales: Moreno-Chicano, Tadeo, Ebrahim, Ali, Axford, Danny, Appleby, Martin V., Beale, John H., Chaplin, Amanda K., Duyvesteyn, Helen M. E., Ghiladi, Reza A., Owada, Shigeki, Sherrell, Darren A., Strange, Richard W., Sugimoto, Hiroshi, Tono, Kensuke, Worrall, Jonathan A. R., Owen, Robin L., Hough, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2019
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830213/
https://www.ncbi.nlm.nih.gov/pubmed/31709063
http://dx.doi.org/10.1107/S2052252519011655

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