Toward G protein-coupled receptor structure-based drug design using X-ray lasers

Rational structure-based drug design (SBDD) relies on the availability of a large number of co-crystal structures to map the ligand-binding pocket of the target protein and use this information for lead-compound optimization via an iterative process. While SBDD has proven successful for many drug-di...

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Detalles Bibliográficos
Autores principales: Ishchenko, Andrii, Stauch, Benjamin, Han, Gye Won, Batyuk, Alexander, Shiriaeva, Anna, Li, Chufeng, Zatsepin, Nadia, Weierstall, Uwe, Liu, Wei, Nango, Eriko, Nakane, Takanori, Tanaka, Rie, Tono, Kensuke, Joti, Yasumasa, Iwata, So, Moraes, Isabel, Gati, Cornelius, Cherezov, Vadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2019
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830214/
https://www.ncbi.nlm.nih.gov/pubmed/31709066
http://dx.doi.org/10.1107/S2052252519013137

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