Cargando…

Prognostic role of the beta-2 adrenergic receptor in clear cell renal cell carcinoma

The beta-2 adrenergic receptor (ADRB2) regulates the proliferation, apoptosis, angiogenesis, migration, and metastasis of cancer cells. However, its function in the progression of clear cell renal cell carcinoma (ccRCC) is unknown. Here, we report that ADRB2 can be a novel prognostic factor for pati...

Descripción completa

Detalles Bibliográficos
Autores principales: Ha, Mihyang, Kim, Dong Woo, Kim, Jayoung, Hong, Chae Mi, Park, Su Min, Woo, In Ae, Kim, Min Yong, Koo, Hyunjun, Namkoong, Jin, Kim, Jaehyun, Han, Myoung-Eun, Song, Parkyong, Hur, Jin, Kang, Chi-Dug, Kim, Yun Hak, Lee, Dongjun, Oh, Sae-Ock
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830282/
https://www.ncbi.nlm.nih.gov/pubmed/31700702
http://dx.doi.org/10.1080/19768354.2019.1658638
_version_ 1783465749673672704
author Ha, Mihyang
Kim, Dong Woo
Kim, Jayoung
Hong, Chae Mi
Park, Su Min
Woo, In Ae
Kim, Min Yong
Koo, Hyunjun
Namkoong, Jin
Kim, Jaehyun
Han, Myoung-Eun
Song, Parkyong
Hur, Jin
Kang, Chi-Dug
Kim, Yun Hak
Lee, Dongjun
Oh, Sae-Ock
author_facet Ha, Mihyang
Kim, Dong Woo
Kim, Jayoung
Hong, Chae Mi
Park, Su Min
Woo, In Ae
Kim, Min Yong
Koo, Hyunjun
Namkoong, Jin
Kim, Jaehyun
Han, Myoung-Eun
Song, Parkyong
Hur, Jin
Kang, Chi-Dug
Kim, Yun Hak
Lee, Dongjun
Oh, Sae-Ock
author_sort Ha, Mihyang
collection PubMed
description The beta-2 adrenergic receptor (ADRB2) regulates the proliferation, apoptosis, angiogenesis, migration, and metastasis of cancer cells. However, its function in the progression of clear cell renal cell carcinoma (ccRCC) is unknown. Here, we report that ADRB2 can be a novel prognostic factor for patients with ccRCC. The differential expression of ADRB2 in low-stage (stages I and II), high-stage (stages III and IV), low-grade (grades I and II), and high-grade (grades III and IV) ccRCC was identified in cohorts of patients from The Cancer Genome Atlas and the International Cancer Genome Consortium. We evaluated ADRB2 expression as a prognostic factor using the Kaplan-Meier survival curve, multivariate analysis, time-dependent area under the curve (AUC) of Uno’s C-index, and AUC of the receiver operating characteristics (ROC) at five years. Kaplan-Meier analysis revealed that reduced ADRB2 expression is associated with poor prognosis in ccRCC patients. Analysis of C-indices and AUC-ROC further confirmed this result. Moreover, multivariate analysis confirmed the prognostic significance of ADRB2 expression. Collectively, these findings suggest that ADRB2 is a potential prognostic factor for ccRCC.
format Online
Article
Text
id pubmed-6830282
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-68302822019-11-07 Prognostic role of the beta-2 adrenergic receptor in clear cell renal cell carcinoma Ha, Mihyang Kim, Dong Woo Kim, Jayoung Hong, Chae Mi Park, Su Min Woo, In Ae Kim, Min Yong Koo, Hyunjun Namkoong, Jin Kim, Jaehyun Han, Myoung-Eun Song, Parkyong Hur, Jin Kang, Chi-Dug Kim, Yun Hak Lee, Dongjun Oh, Sae-Ock Anim Cells Syst (Seoul) Translational Medicine The beta-2 adrenergic receptor (ADRB2) regulates the proliferation, apoptosis, angiogenesis, migration, and metastasis of cancer cells. However, its function in the progression of clear cell renal cell carcinoma (ccRCC) is unknown. Here, we report that ADRB2 can be a novel prognostic factor for patients with ccRCC. The differential expression of ADRB2 in low-stage (stages I and II), high-stage (stages III and IV), low-grade (grades I and II), and high-grade (grades III and IV) ccRCC was identified in cohorts of patients from The Cancer Genome Atlas and the International Cancer Genome Consortium. We evaluated ADRB2 expression as a prognostic factor using the Kaplan-Meier survival curve, multivariate analysis, time-dependent area under the curve (AUC) of Uno’s C-index, and AUC of the receiver operating characteristics (ROC) at five years. Kaplan-Meier analysis revealed that reduced ADRB2 expression is associated with poor prognosis in ccRCC patients. Analysis of C-indices and AUC-ROC further confirmed this result. Moreover, multivariate analysis confirmed the prognostic significance of ADRB2 expression. Collectively, these findings suggest that ADRB2 is a potential prognostic factor for ccRCC. Taylor & Francis 2019-08-25 /pmc/articles/PMC6830282/ /pubmed/31700702 http://dx.doi.org/10.1080/19768354.2019.1658638 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Translational Medicine
Ha, Mihyang
Kim, Dong Woo
Kim, Jayoung
Hong, Chae Mi
Park, Su Min
Woo, In Ae
Kim, Min Yong
Koo, Hyunjun
Namkoong, Jin
Kim, Jaehyun
Han, Myoung-Eun
Song, Parkyong
Hur, Jin
Kang, Chi-Dug
Kim, Yun Hak
Lee, Dongjun
Oh, Sae-Ock
Prognostic role of the beta-2 adrenergic receptor in clear cell renal cell carcinoma
title Prognostic role of the beta-2 adrenergic receptor in clear cell renal cell carcinoma
title_full Prognostic role of the beta-2 adrenergic receptor in clear cell renal cell carcinoma
title_fullStr Prognostic role of the beta-2 adrenergic receptor in clear cell renal cell carcinoma
title_full_unstemmed Prognostic role of the beta-2 adrenergic receptor in clear cell renal cell carcinoma
title_short Prognostic role of the beta-2 adrenergic receptor in clear cell renal cell carcinoma
title_sort prognostic role of the beta-2 adrenergic receptor in clear cell renal cell carcinoma
topic Translational Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830282/
https://www.ncbi.nlm.nih.gov/pubmed/31700702
http://dx.doi.org/10.1080/19768354.2019.1658638
work_keys_str_mv AT hamihyang prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT kimdongwoo prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT kimjayoung prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT hongchaemi prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT parksumin prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT wooinae prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT kimminyong prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT koohyunjun prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT namkoongjin prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT kimjaehyun prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT hanmyoungeun prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT songparkyong prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT hurjin prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT kangchidug prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT kimyunhak prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT leedongjun prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma
AT ohsaeock prognosticroleofthebeta2adrenergicreceptorinclearcellrenalcellcarcinoma