The Deubiquitinating Enzyme Inhibitor PR-619 Enhances the Cytotoxicity of Cisplatin via the Suppression of Anti-Apoptotic Bcl-2 Protein: In Vitro and In Vivo Study

After chemotherapy for the treatment of metastatic bladder urothelial carcinoma (UC), most patients inevitably encounter drug resistance and resultant treatment failure. Deubiquitinating enzymes (DUBs) remove ubiquitin from target proteins and play a critical role in maintaining protein homeostasis....

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Detalles Bibliográficos
Autores principales: Kuo, Kuan-Lin, Liu, Shing-Hwa, Lin, Wei-Chou, Chow, Po-Ming, Chang, Yu-Wei, Yang, Shao-Ping, Shi, Chung-Sheng, Hsu, Chen-Hsun, Liao, Shih-Ming, Chang, Hong-Chiang, Huang, Kuo-How
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830310/
https://www.ncbi.nlm.nih.gov/pubmed/31627336
http://dx.doi.org/10.3390/cells8101268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830310/
https://www.ncbi.nlm.nih.gov/pubmed/31627336
http://dx.doi.org/10.3390/cells8101268

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