Cargando…

Cellular Processing of the ABCG2 Transporter—Potential Effects on Gout and Drug Metabolism

The human ABCG2 is an important plasma membrane multidrug transporter, involved in uric acid secretion, modulation of absorption of drugs, and in drug resistance of cancer cells. Variants of the ABCG2 transporter, affecting cellular processing and trafficking, have been shown to cause gout and incre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mózner, Orsolya, Bartos, Zsuzsa, Zámbó, Boglárka, Homolya, László, Hegedűs, Tamás, Sarkadi, Balázs
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830335/ https://www.ncbi.nlm.nih.gov/pubmed/31597297 http://dx.doi.org/10.3390/cells8101215

Ejemplares similares

Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter
por: Zámbó, Boglárka, et al.
Publicado: (2019)

Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression
por: Zámbó, Boglárka, et al.
Publicado: (2018)

Expression, Function and Trafficking of the Human ABCG2 Multidrug Transporter Containing Mutations in an Unstructured Cytoplasmic Loop
por: Mózner, Orsolya, et al.
Publicado: (2023)

Genetic polymorphisms and decreased protein expression of ABCG2 urate transporters are associated with susceptibility to gout, disease severity and renal-overload hyperuricemia
por: Pálinkás, Márton, et al.
Publicado: (2022)

Modulation of the Human Erythroid Plasma Membrane Calcium Pump (PMCA4b) Expression by Polymorphic Genetic Variants
por: Mózner, Orsolya, et al.
Publicado: (2021)

Identification of Specific Trafficking Defects of Naturally Occurring Variants of the Human ABCG2 Transporter
por: Bartos, Zsuzsa, et al.
Publicado: (2021)

Jump into a New Fold—A Homology Based Model for the ABCG2/BCRP Multidrug Transporter
por: László, Laura, et al.
Publicado: (2016)

Generation of multidrug resistant human tissues by overexpression of the ABCG2 multidrug transporter in embryonic stem cells
por: Erdei, Zsuzsa, et al.
Publicado: (2018)

The Reentry Helix Is Potentially Involved in Cholesterol Sensing of the ABCG1 Transporter Protein
por: Hegyi, Zoltán, et al.
Publicado: (2022)

Potential role of the ABCG2-Q141K polymorphism in type 2 diabetes
por: Szabó, Edit, et al.
Publicado: (2021)

The transport pathway in the ABCG2 protein and its regulation revealed by molecular dynamics simulations
por: Nagy, Tamás, et al.
Publicado: (2020)

A new fluorescent dye accumulation assay for parallel measurements of the ABCG2, ABCB1 and ABCC1 multidrug transporter functions
por: Szabó, Edit, et al.
Publicado: (2018)

Medically Important Alterations in Transport Function and Trafficking of ABCG2
por: Homolya, László
Publicado: (2021)

Functional Cooperativity between ABCG4 and ABCG1 Isoforms
por: Hegyi, Zoltán, et al.
Publicado: (2016)

A Novel Mathematical Model Describing Adaptive Cellular Drug Metabolism and Toxicity in the Chemoimmune System
por: Tóth, Attila, et al.
Publicado: (2015)

Interactions of Potential Anti-COVID-19 Compounds with Multispecific ABC and OATP Drug Transporters
por: Telbisz, Ágnes, et al.
Publicado: (2021)

Nucleotide binding is the critical regulator of ABCG2 conformational transitions
por: Gyöngy, Zsuzsanna, et al.
Publicado: (2023)

Metabolic Interactions of Purine Derivatives with Human ABC Transporter ABCG2: Genetic Testing to Assess Gout Risk
por: Ishikawa, Toshihisa, et al.
Publicado: (2013)

Cellular Localization and Trafficking of the Human ABCG1 Transporter
por: Neufeld, Edward B., et al.
Publicado: (2014)

Expression Levels of the ABCG2 Multidrug Transporter in Human Erythrocytes Correspond to Pharmacologically Relevant Genetic Variations
por: Kasza, Ildikó, et al.
Publicado: (2012)

The importance of transporters and cell polarization for the evaluation of human stem cell-derived hepatic cells
por: Török, György, et al.
Publicado: (2020)

Multiple common and rare variants of ABCG2 cause gout
por: Higashino, Toshihide, et al.
Publicado: (2017)

The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout—An Update
por: Eckenstaler, Robert, et al.
Publicado: (2021)

Alterations of membrane protein expression in red blood cells of Alzheimer's disease patients
por: Várady, György, et al.
Publicado: (2015)

Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium Signaling
por: Szebényi, Kornélia, et al.
Publicado: (2015)

A comprehensive analysis of the association of common variants of ABCG2 with gout
por: Yu, Kuang-Hui, et al.
Publicado: (2017)

ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approaches
por: Cleophas, MC, et al.
Publicado: (2017)

Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout
por: Wrigley, Rebekah, et al.
Publicado: (2020)

ABCG5 and ABCG8 Are Involved in Vitamin K Transport
por: Matsuo, Michinori, et al.
Publicado: (2023)

Familial early-onset hyperuricemia and gout associated with a newly identified dysfunctional variant in urate transporter ABCG2
por: Toyoda, Yu, et al.
Publicado: (2019)

ABCG2 is not able to catalyze glutathione efflux and does not contribute to GSH-dependent collateral sensitivity
por: Gauthier, Charlotte, et al.
Publicado: (2013)

The impact of dysfunctional variants of ABCG2 on hyperuricemia and gout in pediatric-onset patients
por: Stiburkova, Blanka, et al.
Publicado: (2019)

Influence of the ABCG2 gout risk 141 K allele on urate metabolism during a fructose challenge
por: Dalbeth, Nicola, et al.
Publicado: (2014)

Identification of Two Dysfunctional Variants in the ABCG2 Urate Transporter Associated with Pediatric-Onset of Familial Hyperuricemia and Early-Onset Gout
por: Toyoda, Yu, et al.
Publicado: (2021)

Common dysfunctional variants in ABCG2 are a major cause of early-onset gout
por: Matsuo, Hirotaka, et al.
Publicado: (2013)

ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout
por: Matsuo, Hirotaka, et al.
Publicado: (2015)

ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study
por: Chen, Chung-Jen, et al.
Publicado: (2018)

Population-specific association between ABCG2 variants and tophaceous disease in people with gout
por: He, Wendy, et al.
Publicado: (2017)

Epistatic interaction between PKD2 and ABCG2 influences the pathogenesis of hyperuricemia and gout
por: Dong, Zheng, et al.
Publicado: (2020)

Syndecan-4 Modulates Cell Polarity and Migration by Influencing Centrosome Positioning and Intracellular Calcium Distribution
por: Becsky, Daniel, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ql4odeoegp060sic6imegldm22