Development Of Saquinavir Mesylate Nanoemulsion-Loaded Transdermal Films: Two-Step Optimization Of Permeation Parameters, Characterization, And Ex Vivo And In Vivo Evaluation

BACKGROUND: Saquinavir mesylate (SQR) tablets are widely used against human immunodeficiency virus. SQR has bioavailability issues owing to its poor aqueous solubility, extensive first-pass metabolism, and even low gastrointestinal tract permeability and absorption. OBJECTIVE: An in-depth optimizati...

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Detalles Bibliográficos
Autor principal: Hosny, Khaled M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830379/
https://www.ncbi.nlm.nih.gov/pubmed/31802871
http://dx.doi.org/10.2147/IJN.S230747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830379/
https://www.ncbi.nlm.nih.gov/pubmed/31802871
http://dx.doi.org/10.2147/IJN.S230747

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