Prevalence of lifestyle characteristics in glucocorticoid users and non-users: a Danish population-based cross-sectional study

OBJECTIVES: Lifestyle may affect observed associations between glucocorticoid use and adverse events. This study aimed to investigate whether lifestyle differ according to use of systemic glucocorticoids. DESIGN: Population-based cross-sectional study. SETTING: The Central Denmark Region. PARTICIPAN...

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Autores principales: Laugesen, Kristina, Petersen, Irene, Pedersen, Lars, Breinholt Larsen, Finn, Jørgensen, Jens Otto Lunde, Sørensen, Henrik T Toft
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830647/
https://www.ncbi.nlm.nih.gov/pubmed/31662378
http://dx.doi.org/10.1136/bmjopen-2019-030780
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author Laugesen, Kristina
Petersen, Irene
Pedersen, Lars
Breinholt Larsen, Finn
Jørgensen, Jens Otto Lunde
Sørensen, Henrik T Toft
author_facet Laugesen, Kristina
Petersen, Irene
Pedersen, Lars
Breinholt Larsen, Finn
Jørgensen, Jens Otto Lunde
Sørensen, Henrik T Toft
author_sort Laugesen, Kristina
collection PubMed
description OBJECTIVES: Lifestyle may affect observed associations between glucocorticoid use and adverse events. This study aimed to investigate whether lifestyle differ according to use of systemic glucocorticoids. DESIGN: Population-based cross-sectional study. SETTING: The Central Denmark Region. PARTICIPANTS: 30 245 adults (≥25 years of age) who participated in a questionnaire-based public health survey in 2010. OUTCOME MEASURES: Systemic glucocorticoid use was categorised as never use, current use (prescription redemption ≤90 days before completing the questionnaire), recent use (prescription redemption 91–365 days before completing the questionnaire), former use (prescription redemption >365 days before completing the questionnaire) and according to cumulative dose expressed in prednisolone equivalents (<100, 100–499, 500–999, 1000–1999, 2000–4999, ≥5000 mg). We computed the prevalence of lifestyle factors (body mass index, smoking, alcohol intake, physical activity and dietary habits) according to glucocorticoid use. We then estimated age-adjusted prevalence ratios (aPRs) and 95% CIs, comparing the categories of glucocorticoid users versus never users. All analyses were stratified by sex. RESULTS: Of the 30 245 participants (53% women, median age 53 years), 563 (1.9%) were current users, 885 (2.9%) were recent users, 3054 (10%) were former users and 25 743 (85%) were never users. Ever users of glucocorticoids had a slightly higher prevalence of obesity than never users (18% vs 14%, aPR=1.4, 95% CI 1.2 to 1.5 in women and 17% vs 15%, aPR=1.2, 95% CI 1.1 to 1.4 in men). In women, ever users of glucocorticoids had a slightly lower prevalence of high-risk alcohol consumption compared with never users (17% vs 20%, aPR=0.8, 95% CI 0.7 to 1.0). Smoking, diet and physical activity did not differ substantially according to use of glucocorticoids. CONCLUSION: Our study provides a framework for quantifying potential uncontrolled confounding by lifestyle factors in studies of systemic glucocorticoids.
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spelling pubmed-68306472019-11-20 Prevalence of lifestyle characteristics in glucocorticoid users and non-users: a Danish population-based cross-sectional study Laugesen, Kristina Petersen, Irene Pedersen, Lars Breinholt Larsen, Finn Jørgensen, Jens Otto Lunde Sørensen, Henrik T Toft BMJ Open Epidemiology OBJECTIVES: Lifestyle may affect observed associations between glucocorticoid use and adverse events. This study aimed to investigate whether lifestyle differ according to use of systemic glucocorticoids. DESIGN: Population-based cross-sectional study. SETTING: The Central Denmark Region. PARTICIPANTS: 30 245 adults (≥25 years of age) who participated in a questionnaire-based public health survey in 2010. OUTCOME MEASURES: Systemic glucocorticoid use was categorised as never use, current use (prescription redemption ≤90 days before completing the questionnaire), recent use (prescription redemption 91–365 days before completing the questionnaire), former use (prescription redemption >365 days before completing the questionnaire) and according to cumulative dose expressed in prednisolone equivalents (<100, 100–499, 500–999, 1000–1999, 2000–4999, ≥5000 mg). We computed the prevalence of lifestyle factors (body mass index, smoking, alcohol intake, physical activity and dietary habits) according to glucocorticoid use. We then estimated age-adjusted prevalence ratios (aPRs) and 95% CIs, comparing the categories of glucocorticoid users versus never users. All analyses were stratified by sex. RESULTS: Of the 30 245 participants (53% women, median age 53 years), 563 (1.9%) were current users, 885 (2.9%) were recent users, 3054 (10%) were former users and 25 743 (85%) were never users. Ever users of glucocorticoids had a slightly higher prevalence of obesity than never users (18% vs 14%, aPR=1.4, 95% CI 1.2 to 1.5 in women and 17% vs 15%, aPR=1.2, 95% CI 1.1 to 1.4 in men). In women, ever users of glucocorticoids had a slightly lower prevalence of high-risk alcohol consumption compared with never users (17% vs 20%, aPR=0.8, 95% CI 0.7 to 1.0). Smoking, diet and physical activity did not differ substantially according to use of glucocorticoids. CONCLUSION: Our study provides a framework for quantifying potential uncontrolled confounding by lifestyle factors in studies of systemic glucocorticoids. BMJ Publishing Group 2019-10-28 /pmc/articles/PMC6830647/ /pubmed/31662378 http://dx.doi.org/10.1136/bmjopen-2019-030780 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Epidemiology
Laugesen, Kristina
Petersen, Irene
Pedersen, Lars
Breinholt Larsen, Finn
Jørgensen, Jens Otto Lunde
Sørensen, Henrik T Toft
Prevalence of lifestyle characteristics in glucocorticoid users and non-users: a Danish population-based cross-sectional study
title Prevalence of lifestyle characteristics in glucocorticoid users and non-users: a Danish population-based cross-sectional study
title_full Prevalence of lifestyle characteristics in glucocorticoid users and non-users: a Danish population-based cross-sectional study
title_fullStr Prevalence of lifestyle characteristics in glucocorticoid users and non-users: a Danish population-based cross-sectional study
title_full_unstemmed Prevalence of lifestyle characteristics in glucocorticoid users and non-users: a Danish population-based cross-sectional study
title_short Prevalence of lifestyle characteristics in glucocorticoid users and non-users: a Danish population-based cross-sectional study
title_sort prevalence of lifestyle characteristics in glucocorticoid users and non-users: a danish population-based cross-sectional study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830647/
https://www.ncbi.nlm.nih.gov/pubmed/31662378
http://dx.doi.org/10.1136/bmjopen-2019-030780
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