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Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the “von Magnus effect”
Continuous cell culture-based influenza vaccine production could significantly reduce footprint and manufacturing costs compared to current batch processing. However, yields of influenza virus in continuous mode can be affected by oscillations in virus titers caused by periodic accumulation of defec...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830746/ https://www.ncbi.nlm.nih.gov/pubmed/31689309 http://dx.doi.org/10.1371/journal.pone.0224317 |