Cargando…

Efficacy, chondrotoxicity and plasma concentrations of tramadol following intra-articular administration in horses undergoing arthroscopy: preliminary findings

Intra-articular administration of analgesics is performed to ensure good perioperative pain management avoiding undesirable systemic effects. To evaluate the effect of intra-articular injection of tramadol on postoperative pain after arthroscopy in horses and to determine whether tramadol had a loca...

Descripción completa

Detalles Bibliográficos
Autores principales: Di Salvo, Alessandra, Chiaradia, Elisabetta, della Rocca, Giorgia, Giorgi, Mario, Mancini, Francesco, Marenzoni, Maria Luisa, Conti, Maria Beatrice, Nannarone, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831008/
https://www.ncbi.nlm.nih.gov/pubmed/30773122
http://dx.doi.org/10.1080/01652176.2018.1546963
_version_ 1783465873162371072
author Di Salvo, Alessandra
Chiaradia, Elisabetta
della Rocca, Giorgia
Giorgi, Mario
Mancini, Francesco
Marenzoni, Maria Luisa
Conti, Maria Beatrice
Nannarone, Sara
author_facet Di Salvo, Alessandra
Chiaradia, Elisabetta
della Rocca, Giorgia
Giorgi, Mario
Mancini, Francesco
Marenzoni, Maria Luisa
Conti, Maria Beatrice
Nannarone, Sara
author_sort Di Salvo, Alessandra
collection PubMed
description Intra-articular administration of analgesics is performed to ensure good perioperative pain management avoiding undesirable systemic effects. To evaluate the effect of intra-articular injection of tramadol on postoperative pain after arthroscopy in horses and to determine whether tramadol had a local effect. Before the in vivo study, an in vitro test was performed aiming to evaluate the viability of equine chondrocytes after exposure to various concentrations of tramadol. The concentration identified as most appropriate was used to treat the horses’ joints. Twelve horses affected by osteochondrosis were randomly assigned to two groups that were treated intra-articularly at the end of surgery with tramadol (4 mg/mL) and saline, respectively. At predetermined time-points a Composite Pain Scale was applied and blood samples were collected in order to define the extent of tramadol absorption into the systemic circulation. The Mann-Whitney test was used for statistical analysis. Serum of four out of six treated horses revealed traces of tramadol (range 10.6–19.3 ng/mL) sporadically between 0.5 and 4 hours post-treatment, while in the other two horses, no trace of drug was found. Findings suggested that any eventual effect was probably due to local action rather than systemic absorption. The pain scores obtained in tramadol-treated horses were lower between 1 and 6 hours post-administration, than those obtained in the control group, but the differences were not statistically significant. These preliminary results suggest that tramadol, at this concentration, is only mildly beneficial in the pain management of horses after arthroscopy.
format Online
Article
Text
id pubmed-6831008
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-68310082019-11-19 Efficacy, chondrotoxicity and plasma concentrations of tramadol following intra-articular administration in horses undergoing arthroscopy: preliminary findings Di Salvo, Alessandra Chiaradia, Elisabetta della Rocca, Giorgia Giorgi, Mario Mancini, Francesco Marenzoni, Maria Luisa Conti, Maria Beatrice Nannarone, Sara Vet Q Short Communication Intra-articular administration of analgesics is performed to ensure good perioperative pain management avoiding undesirable systemic effects. To evaluate the effect of intra-articular injection of tramadol on postoperative pain after arthroscopy in horses and to determine whether tramadol had a local effect. Before the in vivo study, an in vitro test was performed aiming to evaluate the viability of equine chondrocytes after exposure to various concentrations of tramadol. The concentration identified as most appropriate was used to treat the horses’ joints. Twelve horses affected by osteochondrosis were randomly assigned to two groups that were treated intra-articularly at the end of surgery with tramadol (4 mg/mL) and saline, respectively. At predetermined time-points a Composite Pain Scale was applied and blood samples were collected in order to define the extent of tramadol absorption into the systemic circulation. The Mann-Whitney test was used for statistical analysis. Serum of four out of six treated horses revealed traces of tramadol (range 10.6–19.3 ng/mL) sporadically between 0.5 and 4 hours post-treatment, while in the other two horses, no trace of drug was found. Findings suggested that any eventual effect was probably due to local action rather than systemic absorption. The pain scores obtained in tramadol-treated horses were lower between 1 and 6 hours post-administration, than those obtained in the control group, but the differences were not statistically significant. These preliminary results suggest that tramadol, at this concentration, is only mildly beneficial in the pain management of horses after arthroscopy. Taylor & Francis 2019-02-18 /pmc/articles/PMC6831008/ /pubmed/30773122 http://dx.doi.org/10.1080/01652176.2018.1546963 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Di Salvo, Alessandra
Chiaradia, Elisabetta
della Rocca, Giorgia
Giorgi, Mario
Mancini, Francesco
Marenzoni, Maria Luisa
Conti, Maria Beatrice
Nannarone, Sara
Efficacy, chondrotoxicity and plasma concentrations of tramadol following intra-articular administration in horses undergoing arthroscopy: preliminary findings
title Efficacy, chondrotoxicity and plasma concentrations of tramadol following intra-articular administration in horses undergoing arthroscopy: preliminary findings
title_full Efficacy, chondrotoxicity and plasma concentrations of tramadol following intra-articular administration in horses undergoing arthroscopy: preliminary findings
title_fullStr Efficacy, chondrotoxicity and plasma concentrations of tramadol following intra-articular administration in horses undergoing arthroscopy: preliminary findings
title_full_unstemmed Efficacy, chondrotoxicity and plasma concentrations of tramadol following intra-articular administration in horses undergoing arthroscopy: preliminary findings
title_short Efficacy, chondrotoxicity and plasma concentrations of tramadol following intra-articular administration in horses undergoing arthroscopy: preliminary findings
title_sort efficacy, chondrotoxicity and plasma concentrations of tramadol following intra-articular administration in horses undergoing arthroscopy: preliminary findings
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831008/
https://www.ncbi.nlm.nih.gov/pubmed/30773122
http://dx.doi.org/10.1080/01652176.2018.1546963
work_keys_str_mv AT disalvoalessandra efficacychondrotoxicityandplasmaconcentrationsoftramadolfollowingintraarticularadministrationinhorsesundergoingarthroscopypreliminaryfindings
AT chiaradiaelisabetta efficacychondrotoxicityandplasmaconcentrationsoftramadolfollowingintraarticularadministrationinhorsesundergoingarthroscopypreliminaryfindings
AT dellaroccagiorgia efficacychondrotoxicityandplasmaconcentrationsoftramadolfollowingintraarticularadministrationinhorsesundergoingarthroscopypreliminaryfindings
AT giorgimario efficacychondrotoxicityandplasmaconcentrationsoftramadolfollowingintraarticularadministrationinhorsesundergoingarthroscopypreliminaryfindings
AT mancinifrancesco efficacychondrotoxicityandplasmaconcentrationsoftramadolfollowingintraarticularadministrationinhorsesundergoingarthroscopypreliminaryfindings
AT marenzonimarialuisa efficacychondrotoxicityandplasmaconcentrationsoftramadolfollowingintraarticularadministrationinhorsesundergoingarthroscopypreliminaryfindings
AT contimariabeatrice efficacychondrotoxicityandplasmaconcentrationsoftramadolfollowingintraarticularadministrationinhorsesundergoingarthroscopypreliminaryfindings
AT nannaronesara efficacychondrotoxicityandplasmaconcentrationsoftramadolfollowingintraarticularadministrationinhorsesundergoingarthroscopypreliminaryfindings