Amidst multiple binding orientations on fork DNA, Saccharolobus MCM helicase proceeds N-first for unwinding

DNA replication requires that the duplex genomic DNA strands be separated; a function that is implemented by ring-shaped hexameric helicases in all Domains. Helicases are composed of two domains, an N- terminal DNA binding domain (NTD) and a C- terminal motor domain (CTD). Replication is controlled...

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Detalles Bibliográficos
Autores principales: Perera, Himasha M, Trakselis, Michael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831031/
https://www.ncbi.nlm.nih.gov/pubmed/31661075
http://dx.doi.org/10.7554/eLife.46096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831031/
https://www.ncbi.nlm.nih.gov/pubmed/31661075
http://dx.doi.org/10.7554/eLife.46096

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