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Amidst multiple binding orientations on fork DNA, Saccharolobus MCM helicase proceeds N-first for unwinding
DNA replication requires that the duplex genomic DNA strands be separated; a function that is implemented by ring-shaped hexameric helicases in all Domains. Helicases are composed of two domains, an N- terminal DNA binding domain (NTD) and a C- terminal motor domain (CTD). Replication is controlled...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831031/ https://www.ncbi.nlm.nih.gov/pubmed/31661075 http://dx.doi.org/10.7554/eLife.46096 |