Cargando…

Development and Validation of a Socioeconomic Kidney Transplant Derailers Index

Socioeconomic barriers can prevent successful kidney transplant (KT) but are difficult to measure efficiently in clinical settings. We created and validated an individual-level, single score Kidney Transplant Derailers Index (KTDI) and assessed its association with waitlisting and living donor KT (L...

Descripción completa

Detalles Bibliográficos
Autores principales: Peipert, John D., Beaumont, Jennifer L., Robbins, Mark L., Paiva, Andrea L., Anderson, Crystal, Cui, Yujie, Waterman, Amy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831117/
https://www.ncbi.nlm.nih.gov/pubmed/31773050
http://dx.doi.org/10.1097/TXD.0000000000000927
_version_ 1783465892811636736
author Peipert, John D.
Beaumont, Jennifer L.
Robbins, Mark L.
Paiva, Andrea L.
Anderson, Crystal
Cui, Yujie
Waterman, Amy D.
author_facet Peipert, John D.
Beaumont, Jennifer L.
Robbins, Mark L.
Paiva, Andrea L.
Anderson, Crystal
Cui, Yujie
Waterman, Amy D.
author_sort Peipert, John D.
collection PubMed
description Socioeconomic barriers can prevent successful kidney transplant (KT) but are difficult to measure efficiently in clinical settings. We created and validated an individual-level, single score Kidney Transplant Derailers Index (KTDI) and assessed its association with waitlisting and living donor KT (LDKT) rates. METHODS. The dataset included 733 patients presenting for KT evaluation in a transplant center in California. Exploratory factor analysis was used to identify socioeconomic barriers to KT (derailers) to include in the index. Potential KT derailers included health insurance, employment, financial insecurity, educational attainment, perception of neighborhood safety, access to a vehicle, having a washer/dryer, and quality of social support. Validity was tested with associations between KTDI scores and the following: (1) the Area Deprivation Index (ADI) and (2) time to KT waitlisting and LDKT. RESULTS. Nine derailers were retained, omitting only social support level from the original set. The KTDI was scored by summing the number of derailers endorsed (mean: 3.0; range: 0–9). Black patients had higher estimated KTDI scores than other patient groups (versus White patients, 3.8 versus 2.1; P < 0.001, effect size = 0.81). In addition, the KTDI was associated with the ADI (γ = 0.70, SE = 0.07; P < 0.001). Finally, in comparison to the lower tertile, patients in the upper and middle KTDI tertiles had lower hazard of waitlisting (upper tertile hazard ratio [HR]: 0.34, 95% confidence interval [CI]: 0.25-0.45; middle tertile HR: 0.54, 95% CI: 0.40-0.72) and receiving an LDKT (upper tertile HR: 0.15, 95% CI: 0.08-0.30; middle tertile HR: 0.35, 95% CI: 0.20-0.62). These associations remained significant when adjusting for the ADI and other patient characteristics. CONCLUSIONS. The KTDI is a valid indicator of socioeconomic barriers to KT for individual patients that can be used to identify patients at risk for not receiving a KT.
format Online
Article
Text
id pubmed-6831117
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-68311172019-11-26 Development and Validation of a Socioeconomic Kidney Transplant Derailers Index Peipert, John D. Beaumont, Jennifer L. Robbins, Mark L. Paiva, Andrea L. Anderson, Crystal Cui, Yujie Waterman, Amy D. Transplant Direct Kidney Transplantation Socioeconomic barriers can prevent successful kidney transplant (KT) but are difficult to measure efficiently in clinical settings. We created and validated an individual-level, single score Kidney Transplant Derailers Index (KTDI) and assessed its association with waitlisting and living donor KT (LDKT) rates. METHODS. The dataset included 733 patients presenting for KT evaluation in a transplant center in California. Exploratory factor analysis was used to identify socioeconomic barriers to KT (derailers) to include in the index. Potential KT derailers included health insurance, employment, financial insecurity, educational attainment, perception of neighborhood safety, access to a vehicle, having a washer/dryer, and quality of social support. Validity was tested with associations between KTDI scores and the following: (1) the Area Deprivation Index (ADI) and (2) time to KT waitlisting and LDKT. RESULTS. Nine derailers were retained, omitting only social support level from the original set. The KTDI was scored by summing the number of derailers endorsed (mean: 3.0; range: 0–9). Black patients had higher estimated KTDI scores than other patient groups (versus White patients, 3.8 versus 2.1; P < 0.001, effect size = 0.81). In addition, the KTDI was associated with the ADI (γ = 0.70, SE = 0.07; P < 0.001). Finally, in comparison to the lower tertile, patients in the upper and middle KTDI tertiles had lower hazard of waitlisting (upper tertile hazard ratio [HR]: 0.34, 95% confidence interval [CI]: 0.25-0.45; middle tertile HR: 0.54, 95% CI: 0.40-0.72) and receiving an LDKT (upper tertile HR: 0.15, 95% CI: 0.08-0.30; middle tertile HR: 0.35, 95% CI: 0.20-0.62). These associations remained significant when adjusting for the ADI and other patient characteristics. CONCLUSIONS. The KTDI is a valid indicator of socioeconomic barriers to KT for individual patients that can be used to identify patients at risk for not receiving a KT. Wolters Kluwer Health 2019-10-08 /pmc/articles/PMC6831117/ /pubmed/31773050 http://dx.doi.org/10.1097/TXD.0000000000000927 Text en Copyright © 2019 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Kidney Transplantation
Peipert, John D.
Beaumont, Jennifer L.
Robbins, Mark L.
Paiva, Andrea L.
Anderson, Crystal
Cui, Yujie
Waterman, Amy D.
Development and Validation of a Socioeconomic Kidney Transplant Derailers Index
title Development and Validation of a Socioeconomic Kidney Transplant Derailers Index
title_full Development and Validation of a Socioeconomic Kidney Transplant Derailers Index
title_fullStr Development and Validation of a Socioeconomic Kidney Transplant Derailers Index
title_full_unstemmed Development and Validation of a Socioeconomic Kidney Transplant Derailers Index
title_short Development and Validation of a Socioeconomic Kidney Transplant Derailers Index
title_sort development and validation of a socioeconomic kidney transplant derailers index
topic Kidney Transplantation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831117/
https://www.ncbi.nlm.nih.gov/pubmed/31773050
http://dx.doi.org/10.1097/TXD.0000000000000927
work_keys_str_mv AT peipertjohnd developmentandvalidationofasocioeconomickidneytransplantderailersindex
AT beaumontjenniferl developmentandvalidationofasocioeconomickidneytransplantderailersindex
AT robbinsmarkl developmentandvalidationofasocioeconomickidneytransplantderailersindex
AT paivaandreal developmentandvalidationofasocioeconomickidneytransplantderailersindex
AT andersoncrystal developmentandvalidationofasocioeconomickidneytransplantderailersindex
AT cuiyujie developmentandvalidationofasocioeconomickidneytransplantderailersindex
AT watermanamyd developmentandvalidationofasocioeconomickidneytransplantderailersindex