Use of Tofacitinib for the Treatment of Arthritis Associated With Ulcerative Colitis

Tofacitinib is a Janus kinase 1–3 inhibitor initially approved for the treatment of rheumatoid arthritis and now approved for the treatment of moderately to severely active ulcerative colitis (UC). We present the case of a patient with UC and seronegative inflammatory arthritis in whom arthritis pro...

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Detalles Bibliográficos
Autores principales: Wang, Wenfei, Cleveland, Noa Krugliak, Ollech, Jacob, Rubin, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831149/
https://www.ncbi.nlm.nih.gov/pubmed/31750389
http://dx.doi.org/10.14309/crj.0000000000000226
Descripción
Sumario:Tofacitinib is a Janus kinase 1–3 inhibitor initially approved for the treatment of rheumatoid arthritis and now approved for the treatment of moderately to severely active ulcerative colitis (UC). We present the case of a patient with UC and seronegative inflammatory arthritis in whom arthritis progressed while on vedolizumab and was successfully treated with tofacitinib. This case provides insight into the use of tofacitinib for the treatment of UC and a concomitant extraintestinal manifestation of joint involvement.

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