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Indolent T-cell lymphoproliferative disease with synchronous diffuse large B-cell lymphoma: A case report
RATIONALE: Indolent T-cell lymphoproliferative disease (T-LPD) of gastrointestinal tract is a rare recently described disease that seldom progresses. We report a case of T-LPD with synchronous diffuse large B-cell lymphoma (DLBCL) that cause aggravation of disease. PATIENT CONCERNS: A 46-year-old Ch...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831179/ https://www.ncbi.nlm.nih.gov/pubmed/31027102 http://dx.doi.org/10.1097/MD.0000000000015323 |
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author | Guo, Linjie Wen, Zhonghui Su, Xueying Xiao, Shuyuan Wang, Yufang |
author_facet | Guo, Linjie Wen, Zhonghui Su, Xueying Xiao, Shuyuan Wang, Yufang |
author_sort | Guo, Linjie |
collection | PubMed |
description | RATIONALE: Indolent T-cell lymphoproliferative disease (T-LPD) of gastrointestinal tract is a rare recently described disease that seldom progresses. We report a case of T-LPD with synchronous diffuse large B-cell lymphoma (DLBCL) that cause aggravation of disease. PATIENT CONCERNS: A 46-year-old Chinese male presented with intermittent paraumbilical colic pain, bloating, and occasional diarrhea for 10 years. His condition aggravated with partial bowel obstruction recently. The patient was diagnosed as T-LPD initially based on histological result and T-cell receptor-gamma clonal gene rearrangement test. The patient was followed without chemotherapy. His condition stabilized for 1 year and then deteriorated with small intestine perforation. DIAGNOSIS: The patient was diagnosed as indolent T-LPD and DLBCL finally. INTERVENTIONS: The patient had surgery for intestine perforation and received chemotherapy for DLBCL and T-LPD afterward. OUTCOMES: At 6 months follow-up, the patient continued to have resolution of his symptoms. LESSONS: Early detection of high-grade transformation of T-LPD or the coexistence of aggressive lymphoma is essential for the patient. DLBCL may coexist in the indolent course of T-LPD. The diagnosis of T-LPD should be made cautiously in case with progressing symptoms such as intestinal obstruction. |
format | Online Article Text |
id | pubmed-6831179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-68311792019-11-19 Indolent T-cell lymphoproliferative disease with synchronous diffuse large B-cell lymphoma: A case report Guo, Linjie Wen, Zhonghui Su, Xueying Xiao, Shuyuan Wang, Yufang Medicine (Baltimore) 4500 RATIONALE: Indolent T-cell lymphoproliferative disease (T-LPD) of gastrointestinal tract is a rare recently described disease that seldom progresses. We report a case of T-LPD with synchronous diffuse large B-cell lymphoma (DLBCL) that cause aggravation of disease. PATIENT CONCERNS: A 46-year-old Chinese male presented with intermittent paraumbilical colic pain, bloating, and occasional diarrhea for 10 years. His condition aggravated with partial bowel obstruction recently. The patient was diagnosed as T-LPD initially based on histological result and T-cell receptor-gamma clonal gene rearrangement test. The patient was followed without chemotherapy. His condition stabilized for 1 year and then deteriorated with small intestine perforation. DIAGNOSIS: The patient was diagnosed as indolent T-LPD and DLBCL finally. INTERVENTIONS: The patient had surgery for intestine perforation and received chemotherapy for DLBCL and T-LPD afterward. OUTCOMES: At 6 months follow-up, the patient continued to have resolution of his symptoms. LESSONS: Early detection of high-grade transformation of T-LPD or the coexistence of aggressive lymphoma is essential for the patient. DLBCL may coexist in the indolent course of T-LPD. The diagnosis of T-LPD should be made cautiously in case with progressing symptoms such as intestinal obstruction. Wolters Kluwer Health 2019-04-26 /pmc/articles/PMC6831179/ /pubmed/31027102 http://dx.doi.org/10.1097/MD.0000000000015323 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 4500 Guo, Linjie Wen, Zhonghui Su, Xueying Xiao, Shuyuan Wang, Yufang Indolent T-cell lymphoproliferative disease with synchronous diffuse large B-cell lymphoma: A case report |
title | Indolent T-cell lymphoproliferative disease with synchronous diffuse large B-cell lymphoma: A case report |
title_full | Indolent T-cell lymphoproliferative disease with synchronous diffuse large B-cell lymphoma: A case report |
title_fullStr | Indolent T-cell lymphoproliferative disease with synchronous diffuse large B-cell lymphoma: A case report |
title_full_unstemmed | Indolent T-cell lymphoproliferative disease with synchronous diffuse large B-cell lymphoma: A case report |
title_short | Indolent T-cell lymphoproliferative disease with synchronous diffuse large B-cell lymphoma: A case report |
title_sort | indolent t-cell lymphoproliferative disease with synchronous diffuse large b-cell lymphoma: a case report |
topic | 4500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831179/ https://www.ncbi.nlm.nih.gov/pubmed/31027102 http://dx.doi.org/10.1097/MD.0000000000015323 |
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