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Prognostic value of long non-coding RNA ZEB1-AS1 in Chinese cancer patients: A Meta-analysis

BACKGROUND: Aberrant expression of long non-coding RNA Zinc finger E-box binding homeobox 1 antisense 1 (lncRNA ZEB1-AS1) can be detected in numerous malignancies. Therefore, a meta-analysis had been carried out in this study, aiming to examine the prognostic value of lncRNA ZEB1-AS1 in malignancies...

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Autores principales: Zhou, Xi, Fan, Yang-Hua, Wang, Yan, Wang, Fu, Liu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831238/
https://www.ncbi.nlm.nih.gov/pubmed/31027073
http://dx.doi.org/10.1097/MD.0000000000015251
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author Zhou, Xi
Fan, Yang-Hua
Wang, Yan
Wang, Fu
Liu, Yong
author_facet Zhou, Xi
Fan, Yang-Hua
Wang, Yan
Wang, Fu
Liu, Yong
author_sort Zhou, Xi
collection PubMed
description BACKGROUND: Aberrant expression of long non-coding RNA Zinc finger E-box binding homeobox 1 antisense 1 (lncRNA ZEB1-AS1) can be detected in numerous malignancies. Therefore, a meta-analysis had been carried out in this study, aiming to examine the prognostic value of lncRNA ZEB1-AS1 in malignancies. METHODS: Electronic databases, such as PubMed, OVID as well as Web of Science, had been systemically retrieved from inception to February 14th, 2019. Besides, the hazard ratios (HRs), together with the corresponding 95% confidence intervals (CIs), had also been analyzed for determining the association of lncRNA ZEB1-AS1 expression with the overall survival (OS) and recurrence-free survival (RFS). In addition, the pooled odds ratios (ORs) would also be computed using the Stata SE12.0 software for evaluating the relationship of lncRNA ZEB1-AS1 expression with pathological factors. RESULTS: A total of 21 original studies involving 1801 cancer patients had been enrolled into the current meta-analysis. As suggested by the pooled HR, high expression of lncRNA ZEB1-AS1 had displayed marked correlation with OS (HR = 2.16, 95% CI: 1.89–2.47) among cancer patients, and no significant heterogeneity was detected. Additionally, high expression of lncRNA ZEB1-AS1 was also markedly associated with RFS among cancer patients (pooled HR = 2.55, 95% CI: 1.61–4.03). Besides, the expression of lncRNA ZEB1-AS1 had displayed marked correlation with poor histological grade (PHG) (OR = 2.86, 95% CI: 2.11–3.87), high tumor stage (HTS) (OR = 3.81, 95% CI: 2.72–5.34) as well as lymph node metastasis (LNM) (OR = 3.33, 95% CI: 2.47–4.49). Additionally, no distinct asymmetry had been detected for RFS, PHG as well as HTS based on Begg funnel plot. CONCLUSIONS: Taken together, high expression of lncRNA ZEB1-AS1 can predict the dismal OS, RFS, LNM, PHG, and HTS, indicating that lncRNA ZEB1-AS1 can be potentially used as a new biomarker to predict the dismal prognosis for cancer patients.
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spelling pubmed-68312382019-11-19 Prognostic value of long non-coding RNA ZEB1-AS1 in Chinese cancer patients: A Meta-analysis Zhou, Xi Fan, Yang-Hua Wang, Yan Wang, Fu Liu, Yong Medicine (Baltimore) 5700 BACKGROUND: Aberrant expression of long non-coding RNA Zinc finger E-box binding homeobox 1 antisense 1 (lncRNA ZEB1-AS1) can be detected in numerous malignancies. Therefore, a meta-analysis had been carried out in this study, aiming to examine the prognostic value of lncRNA ZEB1-AS1 in malignancies. METHODS: Electronic databases, such as PubMed, OVID as well as Web of Science, had been systemically retrieved from inception to February 14th, 2019. Besides, the hazard ratios (HRs), together with the corresponding 95% confidence intervals (CIs), had also been analyzed for determining the association of lncRNA ZEB1-AS1 expression with the overall survival (OS) and recurrence-free survival (RFS). In addition, the pooled odds ratios (ORs) would also be computed using the Stata SE12.0 software for evaluating the relationship of lncRNA ZEB1-AS1 expression with pathological factors. RESULTS: A total of 21 original studies involving 1801 cancer patients had been enrolled into the current meta-analysis. As suggested by the pooled HR, high expression of lncRNA ZEB1-AS1 had displayed marked correlation with OS (HR = 2.16, 95% CI: 1.89–2.47) among cancer patients, and no significant heterogeneity was detected. Additionally, high expression of lncRNA ZEB1-AS1 was also markedly associated with RFS among cancer patients (pooled HR = 2.55, 95% CI: 1.61–4.03). Besides, the expression of lncRNA ZEB1-AS1 had displayed marked correlation with poor histological grade (PHG) (OR = 2.86, 95% CI: 2.11–3.87), high tumor stage (HTS) (OR = 3.81, 95% CI: 2.72–5.34) as well as lymph node metastasis (LNM) (OR = 3.33, 95% CI: 2.47–4.49). Additionally, no distinct asymmetry had been detected for RFS, PHG as well as HTS based on Begg funnel plot. CONCLUSIONS: Taken together, high expression of lncRNA ZEB1-AS1 can predict the dismal OS, RFS, LNM, PHG, and HTS, indicating that lncRNA ZEB1-AS1 can be potentially used as a new biomarker to predict the dismal prognosis for cancer patients. Wolters Kluwer Health 2019-04-26 /pmc/articles/PMC6831238/ /pubmed/31027073 http://dx.doi.org/10.1097/MD.0000000000015251 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 5700
Zhou, Xi
Fan, Yang-Hua
Wang, Yan
Wang, Fu
Liu, Yong
Prognostic value of long non-coding RNA ZEB1-AS1 in Chinese cancer patients: A Meta-analysis
title Prognostic value of long non-coding RNA ZEB1-AS1 in Chinese cancer patients: A Meta-analysis
title_full Prognostic value of long non-coding RNA ZEB1-AS1 in Chinese cancer patients: A Meta-analysis
title_fullStr Prognostic value of long non-coding RNA ZEB1-AS1 in Chinese cancer patients: A Meta-analysis
title_full_unstemmed Prognostic value of long non-coding RNA ZEB1-AS1 in Chinese cancer patients: A Meta-analysis
title_short Prognostic value of long non-coding RNA ZEB1-AS1 in Chinese cancer patients: A Meta-analysis
title_sort prognostic value of long non-coding rna zeb1-as1 in chinese cancer patients: a meta-analysis
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831238/
https://www.ncbi.nlm.nih.gov/pubmed/31027073
http://dx.doi.org/10.1097/MD.0000000000015251
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