Aldehyde dehydrogenase 1A1 confers erlotinib resistance via facilitating the reactive oxygen species-reactive carbonyl species metabolic pathway in lung adenocarcinomas

Background: Acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) such as erlotinib is a major challenge to achieve an overall clinical benefit of the targeted therapy. Recently, aldehyde dehydrogenase 1 (ALDH1) induction has been found to render lung adeno...

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Detalles Bibliográficos
Autores principales: Lei, Hui-Min, Zhang, Ke-Ren, Wang, Cong Hui, Wang, Yang, Zhuang, Guang-Lei, Lu, Li-Ming, Zhang, Jian, Shen, Ying, Chen, Hong-Zhuan, Zhu, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831290/
https://www.ncbi.nlm.nih.gov/pubmed/31695757
http://dx.doi.org/10.7150/thno.35729

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